高脂饮食单独对动物模型中脂质、动脉壁和海马神经细胞改变的作用及其对人类的影响。
Role of High-Fat Diet Alone on Lipids, Arterial Wall and Hippocampal Neural Cell Alterations in Animal Models and Their Implications for Humans.
作者信息
Prabhu Gayathri S, Rao Kg Mohandas, Concessao Preethi Lavina, Rai Kiranmai S
机构信息
Division of Anatomy, Department of Basic Medical Sciences, Manipal Academy of Higher Education, Manipal 576104, India.
Division of Physiology, Department of Basic Medical Sciences, Manipal Academy of Higher Education, Manipal 576104, India.
出版信息
Biology (Basel). 2025 Aug 1;14(8):971. doi: 10.3390/biology14080971.
BACKGROUND
A high-fat diet has been shown to have an impact on metabolism resulting in changes in arterial wall thickness and degeneration of surviving neural cells of the hippocampus. The present review focuses on the various animal models used to induce high-fat diet conditions for studying obesity-induced atherosclerosis, along with the associated changes observed in surviving neural cells of the hippocampus. It also highlights the limitations of rodent models and discusses their implications for human research.
METHODS
The sources for the literature search were Scopus, PubMed, Medline and Google Scholar. Both animal and human studies published were considered and are cited.
RESULTS
High-fat-diet-induced vascular changes, mainly in the tunica media, has been shown to have more impact on medium-sized arteries and on the Cornu Ammonis three subregions and outer dentatae gyrus of the hippocampus.
CONCLUSIONS
High-fat-diet-induced neurovascular changes have been studied radically in animal models, and more supporting studies representing preclinical research should be advanced to humans.
背景
高脂饮食已被证明会对新陈代谢产生影响，导致动脉壁厚度改变以及海马体存活神经细胞退化。本综述聚焦于用于诱导高脂饮食条件以研究肥胖诱导的动脉粥样硬化的各种动物模型，以及在海马体存活神经细胞中观察到的相关变化。它还强调了啮齿动物模型的局限性，并讨论了其对人体研究的影响。
方法
文献检索来源为Scopus、PubMed、Medline和谷歌学术。已发表的动物和人体研究均被考虑并引用。
结果
高脂饮食诱导的血管变化主要发生在中膜，已被证明对中等大小动脉以及海马体的海马角三个亚区和外齿状回有更大影响。
结论
高脂饮食诱导的神经血管变化在动物模型中已得到深入研究，更多代表临床前研究的支持性研究应推进到人体研究。
Zotero 插件