Falagas Matthew E, Kontogiannis Dimitrios S, Sargianou Maria, Falaga Evanthia M, Chatzimichali Maria, Michaeloudes Charalambos
Alfa Institute of Biomedical Sciences (AIBS), 9 Neapoleos Street, Marousi, 151 23 Athens, Greece.
School of Medicine, European University Cyprus, Nicosia 2404, Cyprus.
Biology (Basel). 2025 Aug 13;14(8):1043. doi: 10.3390/biology14081043.
Novel infection control practices are necessary to reduce the incidence of healthcare-associated infections (HAIs). Since 2007, probiotic-based cleaning solutions have been proposed as an alternative to traditional methods using disinfectants and detergents in healthcare settings, including hospitals. We conducted a comprehensive search across Google Scholar, PubMed, Scopus, and Web of Science resources. Studies that assessed the reduction in pathogens on surfaces and the emergence of HAIs after the use of probiotic-based cleaning solutions were eligible for evaluation. A total of 16 studies (13 in clinical settings and 3 on experimental surfaces) were included. The species were most commonly identified before and after the use of probiotic-based cleaning solutions. All studies showed numerically lower pathogen counts and fewer HAIs after using probiotic-based cleaning solutions compared to disinfectants and detergents. Three studies indicated a reduction in antimicrobial resistance genes after use of probiotic-based cleaning solutions. One of these showed statistically significant differences compared to traditional disinfectants (alcohol, amines, and quaternary ammonium compounds) and detergents (non-ionic and anionic surfactants). The results of the included studies suggest the consideration of probiotic-based cleaning solutions for infection control in healthcare systems. However, given the novelty of this approach, further studies are needed to verify the evaluated findings and investigate the short- and long-term effectiveness, and safety of probiotic-based cleaning solutions on infection control practices in healthcare settings.
需要采用新的感染控制措施来降低医疗相关感染（HAIs）的发生率。自2007年以来，基于益生菌的清洁溶液被提议作为医疗环境（包括医院）中使用消毒剂和洗涤剂的传统方法的替代方案。我们在谷歌学术、PubMed、Scopus和科学网资源中进行了全面检索。评估使用基于益生菌的清洁溶液后表面病原体减少情况以及HAIs出现情况的研究符合评估条件。共纳入16项研究（13项在临床环境中，3项在实验表面上）。在使用基于益生菌的清洁溶液前后最常鉴定出的菌种。与消毒剂和洗涤剂相比，所有研究均显示使用基于益生菌的清洁溶液后病原体数量在数值上更低，HAIs也更少。三项研究表明使用基于益生菌的清洁溶液后抗菌抗性基因减少。其中一项研究显示与传统消毒剂（酒精、胺类和季铵化合物）和洗涤剂（非离子和阴离子表面活性剂）相比有统计学显著差异。纳入研究的结果表明在医疗系统中考虑使用基于益生菌的清洁溶液进行感染控制。然而，鉴于这种方法的新颖性，需要进一步研究来验证评估结果，并调查基于益生菌的清洁溶液在医疗环境感染控制实践中的短期和长期有效性及安全性。
