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社区居住老年人生活质量的年龄相关轨迹:来自欧洲健康、老龄化与退休调查(SHARE)的发现。

Age-related trajectories of quality of life in community dwelling older adults: findings from the Survey of Health, Aging and Retirement in Europe (SHARE).

作者信息

Mendorf Sarah, Heimrich Konstantin G, Mühlhammer Hannah M, Prell Tino, Schönenberg Aline

机构信息

Department of Geriatrics, University Hospital Jena, Jena, Germany.

Department of Neurology, University Hospital Jena, Jena, Germany.

出版信息

Front Aging Neurosci. 2025 Aug 20;17:1632607. doi: 10.3389/fnagi.2025.1632607. eCollection 2025.

Abstract

INTRODUCTION

Previous longitudinal studies have identified numerous factors influencing quality of life (QoL) in people of older age (PoA). However, most of these studies focus on group-level trends and fail to consider individual QoL trajectories or age-specific patterns over time.

METHODS

We investigated longitudinal changes in QoL among community-dwelling older adults using five waves (2010-2019) of the Survey of Health, Aging and Retirement in Europe (easySHARE). Clinically relevant changes were defined via the minimal clinically important difference (MCID). We applied linear regression and linear mixed models (LMM) to explore predictors of QoL trajectories.

RESULTS

Descriptive analyses showed that 2481 PoA (19.7%) experienced stable QoL between waves, based on changes below the MCID threshold of 3.18 points. The remaining participants exhibited consistent improvements or declines, with 1,701 different longitudinal patterns of QoL identified across the five time points. These individual patterns were further examined using LMM. LMM showed that the random effect of ID had the strongest impact on QoL across the five waves, suggesting highly individual QoL patterns. The influence of age was less significant compared to ID and decreased significantly after the addition of covariates.

CONCLUSION

Our findings underscore the importance of individual-level analyses in aging research. While QoL may appear stable at the group level, individual trajectories vary considerably. This has important implications for the use of QoL as a primary endpoint in clinical trials, particularly in geriatric populations. Notably, age alone did not significantly influence QoL over time.

摘要

引言

以往的纵向研究已经确定了许多影响老年人生活质量(QoL)的因素。然而,这些研究大多关注群体层面的趋势,未能考虑个体生活质量轨迹或随时间变化的特定年龄模式。

方法

我们使用欧洲健康、老龄化和退休调查(easySHARE)的五轮调查(2010 - 2019年),研究了社区居住的老年人生活质量的纵向变化。通过最小临床重要差异(MCID)定义临床相关变化。我们应用线性回归和线性混合模型(LMM)来探索生活质量轨迹的预测因素。

结果

描述性分析表明,基于低于3.18分的MCID阈值的变化,2481名老年人(19.7%)在各轮调查之间经历了稳定的生活质量。其余参与者表现出持续的改善或下降,在五个时间点共识别出1701种不同的生活质量纵向模式。使用LMM对这些个体模式进行了进一步研究。LMM显示,在五轮调查中,ID的随机效应对生活质量的影响最强,表明生活质量模式具有高度个体性。与ID相比,年龄的影响较小,在加入协变量后显著降低。

结论

我们的研究结果强调了个体层面分析在衰老研究中的重要性。虽然在群体层面生活质量可能看起来稳定,但个体轨迹差异很大。这对将生活质量作为临床试验的主要终点,特别是在老年人群体中的应用具有重要意义。值得注意的是,仅年龄本身并不会随着时间的推移对生活质量产生显著影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aef8/12405344/60aed62af41f/fnagi-17-1632607-g001.jpg

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