Li Xiaoyan, Chen Peng, Wang Shaosong, Wang Chunchen, Li Bin, Liu Huilin
Department of Acupuncture and Moxibustion, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing Key Laboratory of Acupuncture Neuromodulation, Beijing, People's Republic of China.
Neuropsychiatr Dis Treat. 2025 Aug 29;21:1799-1822. doi: 10.2147/NDT.S541627. eCollection 2025.
Recently, research on the management of Parkinson's disease (PD), particularly non-motor symptoms (NMS), has been increasingly reported. This systematic review and network meta-analysis (NMA) aimed to evaluate the efficacy of acupuncture interventions for NMS in PD patients to identify the most effective strategy.
Randomized controlled trials (RCTs) on acupuncture for NMS in PD were retrieved up to July 31, 2024, across eight databases: PubMed, Embase (OVID), Cochrane Library, Web of Science, China National Knowledge Infrastructure, Chinese Biomedical Literature Database, VIP Database, and Wanfang Database. The quality of the included studies was assessed using the Cochrane handbook for systematic reviews.
77 RCTs were included, involving 5538 PD patients. The NMA indicated that acupuncture_training_usual ([SUCRA] = 84.18%) was the best intervention for improving the anxiety state of PD patients. Abdominal_acupuncture_usual (94.15%) was a preferred intervention for improving the depressive state. Scalp_acupuncture_usual (99.98%) and Scalp_electroacupuncture (94.28%) can significantly improve the sleep quality of PD patients. Heat_sensitive_moxibustion_usual (94.65%) and Warm_acupuncture_moxibustion_usual (99.995%) can significantly improve the quality of life of PD patients. Acupuncture_usual (94.02%) may be considered a promising intervention for improving the psychological, emotional and cognitive functions. Additionally, shallow_acupuncture_usual (99.17%) was the safest option. Notably, acupuncture_moxibustion (98.24%) was the most effective intervention involving the largest number of participants.
This analysis identifies the most effective acupuncture interventions for improving NMS in PD patients, including anxiety, depression, sleep quality, and overall quality of life, as well as additional benefits in pain management and gastrointestinal function. Future large-scale RCTs are needed to confirm these findings.
近年来，关于帕金森病（PD）管理的研究，尤其是非运动症状（NMS）的研究报道日益增多。本系统评价和网状Meta分析（NMA）旨在评估针刺干预对PD患者NMS的疗效，以确定最有效的策略。
截至2024年7月31日，通过八个数据库检索关于针刺治疗PD患者NMS的随机对照试验（RCT）：PubMed、Embase（OVID）、Cochrane图书馆、科学网、中国知网、中国生物医学文献数据库、维普数据库和万方数据库。使用Cochrane系统评价手册评估纳入研究的质量。
纳入77项RCT，涉及5538例PD患者。NMA表明，针刺训练常规治疗（[累积排序曲线下面积（SUCRA）]=84.18%）是改善PD患者焦虑状态的最佳干预措施。腹针常规治疗（94.15%）是改善抑郁状态的首选干预措施。头针常规治疗（99.98%）和头皮电针（94.28%）可显著改善PD患者的睡眠质量。热敏灸常规治疗（94.65%）和温针灸常规治疗（99.995%）可显著改善PD患者的生活质量。针刺常规治疗（94.02%）可能是改善心理、情绪和认知功能的有前景的干预措施。此外，浅针常规治疗（99.17%）是最安全的选择。值得注意的是，针灸（98.24%）是涉及参与者数量最多的最有效干预措施。
本分析确定了改善PD患者NMS最有效的针刺干预措施，包括焦虑、抑郁、睡眠质量和总体生活质量，以及在疼痛管理和胃肠功能方面的额外益处。未来需要大规模RCT来证实这些发现。
