Sládek Vladimír, Hora Martin, Wall-Scheffler Cara, Struška Michal, Berner Margit
Department of Anthropology and Human Genetics, Faculty of Science, Charles University, Viničná 7, 128 43 Prague, Czech Republic.
Department of Biology, Seattle Pacific University, Seattle, WA 98119, USA.
Sci Adv. 2025 Sep 5;11(36):eadx7981. doi: 10.1126/sciadv.adx7981.
Age-related deterioration in bone strength among Western humans has been linked with sedentary lifestyles, but the effect remains debatable. We evaluated aging of diaphyseal strength and cortical bone loss in a European Holocene sample of 1881 adult humeri, femora, and tibiae. Diaphyseal aging did not differ between Early and Late Holocene adults, despite their differences in physical activity. Adult diaphyseal aging was accompanied by the disproportionate rate between a faster increase in the medullary area and an absent or marginal increase in the total area. This indicates that subperiosteal apposition did not fully biomechanically compensate for the medullary expansion. Diaphyseal strength remained unchanged through age in female femora and male diaphyses but declined in female humeri and tibiae. We highlight the importance of postnatal growth to compensate for adult medullary expansion. Diaphyseal aging is critical for the upper limbs, as humeri are more sensitive to aging than femora and tibiae.
西方人群中与年龄相关的骨强度下降与久坐不动的生活方式有关，但这种影响仍存在争议。我们评估了欧洲全新世样本中1881根成人肱骨、股骨和胫骨骨干强度的老化以及皮质骨丢失情况。尽管全新世早期和晚期成年人的身体活动存在差异，但骨干老化情况并无不同。成人骨干老化伴随着髓腔面积更快增加与总面积无增加或仅有少量增加之间的不成比例速率。这表明骨膜下增生在生物力学上并未完全补偿髓腔扩张。女性股骨和男性骨干的骨干强度随年龄保持不变，但女性肱骨和胫骨的骨干强度下降。我们强调了出生后生长对补偿成人髓腔扩张的重要性。骨干老化对上肢至关重要，因为肱骨比股骨和胫骨对老化更敏感。
