骨钙素要实现γ-羧化有很多窍门。 - Suppr

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超能文献

Osteocalcin has many tricks to get γ-carboxylated.

作者信息

Ferron Mathieu

机构信息

Institut de Recherches Cliniques de Montréal, Montréal, QC, Canada.

Département de Médecine, Université de Montréal, Montréal, QC, Canada.

出版信息

Cell Res. 2025 Sep 5. doi: 10.1038/s41422-025-01177-6.

DOI:10.1038/s41422-025-01177-6

PMID:40913186

Abstract

摘要

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Molecular basis of vitamin-K-driven γ-carboxylation at the membrane interface.维生素K驱动的膜界面γ羧化作用的分子基础。

Nature. 2025 Mar;639(8055):816-824. doi: 10.1038/s41586-025-08648-1. Epub 2025 Jan 29.

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Diabetes. 2024 Oct 1;73(10):1648-1661. doi: 10.2337/db23-0802.

Osteocalcin: A Multifaceted Bone-Derived Hormone.骨钙素：一种多效性的骨骼衍生激素。

Annu Rev Nutr. 2023 Aug 21;43:55-71. doi: 10.1146/annurev-nutr-061121-091348.

Vitamin K-dependent carboxylation regulates Ca flux and adaptation to metabolic stress in β cells.维生素 K 依赖性羧化作用调节β细胞中的钙流和代谢应激适应。

Cell Rep. 2023 May 30;42(5):112500. doi: 10.1016/j.celrep.2023.112500. Epub 2023 May 11.

Vitamin K-Dependent Protein Activation: Normal Gamma-Glutamyl Carboxylation and Disruption in Disease.维生素 K 依赖性蛋白激活：正常 γ-谷氨酰羧化和疾病中的破坏。

Int J Mol Sci. 2022 May 20;23(10):5759. doi: 10.3390/ijms23105759.

Osteocalcin affects bone mineral and mechanical properties in female mice.骨钙素影响雌性小鼠的骨矿物质和力学性能。

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