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Osteocalcin has many tricks to get γ-carboxylated.

作者信息

Ferron Mathieu

机构信息

Institut de Recherches Cliniques de Montréal, Montréal, QC, Canada.

Département de Médecine, Université de Montréal, Montréal, QC, Canada.

出版信息

Cell Res. 2025 Sep 5. doi: 10.1038/s41422-025-01177-6.

DOI:10.1038/s41422-025-01177-6
PMID:40913186
Abstract
摘要

相似文献

1
Osteocalcin has many tricks to get γ-carboxylated.骨钙素要实现γ-羧化有很多窍门。
Cell Res. 2025 Sep 5. doi: 10.1038/s41422-025-01177-6.
2
Higher carboxylated osteocalcin is an independent predictor of improved femoral bone strength: A cross-sectional study.
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Intake of fermented soybean (natto) increases circulating vitamin K2 (menaquinone-7) and gamma-carboxylated osteocalcin concentration in normal individuals.正常个体摄入发酵大豆（纳豆）可增加循环维生素K2（甲萘醌-7）和γ-羧化骨钙素浓度。
J Bone Miner Metab. 2000;18(4):216-22. doi: 10.1007/s007740070023.
4
Gamma-carboxylation of osteocalcin and insulin resistance in older men and women.骨钙素的γ-羧化作用与老年男女的胰岛素抵抗。
Am J Clin Nutr. 2009 Nov;90(5):1230-5. doi: 10.3945/ajcn.2009.28151. Epub 2009 Sep 23.
5
The uncarboxylated form of osteocalcin is associated with improved glucose tolerance and enhanced beta-cell function in middle-aged male subjects.非羧化骨钙素与中年男性葡萄糖耐量改善和β细胞功能增强相关。
Diabetes Metab Res Rev. 2009 Nov;25(8):768-72. doi: 10.1002/dmrr.1045.
6
Lower uncarboxylated osteocalcin concentrations in children with prediabetes is associated with beta-cell function.骨钙素低羧化浓度在儿童糖尿病前期与β细胞功能相关。
J Clin Endocrinol Metab. 2011 Jul;96(7):E1092-9. doi: 10.1210/jc.2010-2731. Epub 2011 Apr 20.
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The proportion of carboxylated to total or intact osteocalcin in serum discriminates warfarin-treated patients from control subjects.
J Bone Miner Res. 1999 Apr;14(4):555-60. doi: 10.1359/jbmr.1999.14.4.555.
8
Low-Dose Daily Intake of Vitamin K(2) (Menaquinone-7) Improves Osteocalcin γ-Carboxylation: A Double-Blind, Randomized Controlled Trials.每日低剂量摄入维生素K(2)（甲萘醌-7）可改善骨钙素γ-羧化：一项双盲、随机对照试验。
J Nutr Sci Vitaminol (Tokyo). 2015;61(6):471-80. doi: 10.3177/jnsv.61.471.
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Carboxylated and uncarboxylated forms of osteocalcin directly modulate the glucose transport system and inflammation in adipocytes.羧化和未羧化形式的骨钙素直接调节脂肪细胞中的葡萄糖转运系统和炎症反应。
Horm Metab Res. 2014 May;46(5):341-7. doi: 10.1055/s-0034-1368709. Epub 2014 Feb 19.
10
Structural insights into the vitamin K-dependent γ-carboxylation of osteocalcin.骨钙素维生素K依赖性γ羧化作用的结构见解
Cell Res. 2025 Sep 2. doi: 10.1038/s41422-025-01161-0.

本文引用的文献

1
Structural insights into the vitamin K-dependent γ-carboxylation of osteocalcin.骨钙素维生素K依赖性γ羧化作用的结构见解
Cell Res. 2025 Sep 2. doi: 10.1038/s41422-025-01161-0.
2
Molecular basis of vitamin-K-driven γ-carboxylation at the membrane interface.维生素K驱动的膜界面γ羧化作用的分子基础。
Nature. 2025 Mar;639(8055):816-824. doi: 10.1038/s41586-025-08648-1. Epub 2025 Jan 29.
3
GAS6 and AXL Promote Insulin Resistance by Rewiring Insulin Signaling and Increasing Insulin Receptor Trafficking to Endosomes.Gas6 和 AXL 通过重新布线胰岛素信号和增加胰岛素受体向内体的运输来促进胰岛素抵抗。
Diabetes. 2024 Oct 1;73(10):1648-1661. doi: 10.2337/db23-0802.
4
Osteocalcin: A Multifaceted Bone-Derived Hormone.骨钙素：一种多效性的骨骼衍生激素。
Annu Rev Nutr. 2023 Aug 21;43:55-71. doi: 10.1146/annurev-nutr-061121-091348.
5
Vitamin K-dependent carboxylation regulates Ca flux and adaptation to metabolic stress in β cells.维生素 K 依赖性羧化作用调节β细胞中的钙流和代谢应激适应。
Cell Rep. 2023 May 30;42(5):112500. doi: 10.1016/j.celrep.2023.112500. Epub 2023 May 11.
6
Vitamin K-Dependent Protein Activation: Normal Gamma-Glutamyl Carboxylation and Disruption in Disease.维生素 K 依赖性蛋白激活：正常 γ-谷氨酰羧化和疾病中的破坏。
Int J Mol Sci. 2022 May 20;23(10):5759. doi: 10.3390/ijms23105759.
7
Osteocalcin affects bone mineral and mechanical properties in female mice.骨钙素影响雌性小鼠的骨矿物质和力学性能。
Bone. 2019 Nov;128:115031. doi: 10.1016/j.bone.2019.08.004. Epub 2019 Aug 8.
8
Regulation of Energy Metabolism by Bone-Derived Hormones.骨源激素对能量代谢的调节。
Cold Spring Harb Perspect Med. 2018 Jun 1;8(6):a031666. doi: 10.1101/cshperspect.a031666.
9
Association between osteocalcin gamma-carboxylation and insulin resistance in overweight and obese postmenopausal women.超重和肥胖绝经后女性骨钙素γ-羧化与胰岛素抵抗之间的关联
J Diabetes Complications. 2017 Jun;31(6):1027-1034. doi: 10.1016/j.jdiacomp.2017.01.023. Epub 2017 Feb 13.
10
In vivo analysis of the contribution of bone resorption to the control of glucose metabolism in mice.在体分析骨吸收对小鼠葡萄糖代谢控制的作用。
Mol Metab. 2013 Aug 15;2(4):498-504. doi: 10.1016/j.molmet.2013.08.004. eCollection 2013.