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[使用佐剂或非佐剂疫苗进行初次抗狂犬病疫苗接种后犬的血清学反应]

[Serological response of the dog after primary antirabies vaccination using adjuvant or non-adjuvant vaccines].

作者信息

Koutchoukali M A, Blancou J, Chappuis G, Tixier G, Eloit M, Ganiere J P, Chantal J, Simon S, Berthier A, Toma B

出版信息

Ann Rech Vet. 1985;16(4):345-9.

PMID:4091488
Abstract

The serological responses following a primary vaccination carried out one year before in two groups of dogs which received an inactivated cell culture vaccine containing or not an adjuvant (alumine-hydroxide) are compared. Neutralizing antibody titers assayed in mice, obtained with only one injection of the adjuvanted vaccine are at the same or a greater level than those induced by two injections of the non-adjuvanted vaccine administered two to four weeks apart (statutory schedule of rabies primary vaccination applied in France).

摘要

对两组犬进行比较,这两组犬在一年前接种了含或不含佐剂(氢氧化铝)的灭活细胞培养疫苗进行初次免疫,之后检测其血清学反应。在小鼠中检测的中和抗体滴度显示,仅注射一次含佐剂疫苗所获得的滴度与按照法国狂犬病初次免疫法定程序,间隔两至四周注射两次不含佐剂疫苗所诱导的滴度相同或更高。

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