Moghissi K S, Sacco A G, Borin K
Am J Obstet Gynecol. 1980 Apr 1;136(7):941-50.
SAA and SIA were assayed in the sera of 172 infertile couples and in the CM of the women and 18 control subjects. Complete infertility evaluation was performed in all subjects except the controls. Results of these studies were correlated with PCT's. Sperm antibodies were detected in the CM of 25.6% of infertile women and in the sera of 12.7% of female and 6.4% of male subjects. No sperm antibodies were found in the CM of controls. Sperm antibodies were present exclusively in sera of 8.1% of women and in the CM of 20.9%. In only 4.7% both serum and CM contained antibodies. A significantly higher incidence of sperm antibodies was found in the sera of women and in CM and sera of all couples with unexplained infertility compared to those with explained infertility. The presence and the number of liver spermatozoa in CM collected for PCT's were found to be significantly related to the existence of SAA and SIA in CM and serum. Stepwise multiple regression analysis indicated that SAA or SIA antibodies in CM and SAA in female serum have a significant negative correlation with endocervical PCT, whereas sperm motility has a positive correlation. These factors, together, accounted for 24.5% of variance. These data indicate that the appearance of SAA and SIA in CM is not related to their presence or titer in blood serum and that the PCT is a reliable screening method when sperm antibodies are suspected to exist in CM and to a lesser extent in serum.
对172对不孕夫妇的血清、女性宫颈黏液及18名对照者进行了精子抗体（SAA）和精子免疫珠试验（SIA）检测。除对照者外，对所有受试者均进行了全面的不孕评估。这些研究结果与宫颈黏液穿透试验（PCT）结果相关。在25.6%的不孕女性宫颈黏液、12.7%的女性血清和6.4%的男性血清中检测到精子抗体。对照者的宫颈黏液中未发现精子抗体。仅8.1%的女性血清、20.9%的女性宫颈黏液中存在精子抗体。仅4.7%的女性血清和宫颈黏液中均含有抗体。与有明确病因的不孕夫妇相比，不明原因不孕夫妇的女性血清、宫颈黏液和血清中精子抗体的发生率显著更高。发现用于PCT检测所收集的宫颈黏液中活精子的存在及数量与宫颈黏液和血清中SAA及SIA的存在显著相关。逐步多元回归分析表明，宫颈黏液中的SAA或SIA抗体以及女性血清中的SAA与宫颈内PCT呈显著负相关，而精子活力呈正相关。这些因素共同解释了24.5%的变异。这些数据表明，宫颈黏液中SAA和SIA的出现与血清中它们的存在或滴度无关，并且当怀疑宫颈黏液中存在精子抗体且血清中存在程度较低时，PCT是一种可靠的筛查方法。
