Chakraborty R, Gershowitz H, Ferrell R E, Barton S A, Schull W J
Ann Hum Biol. 1985 Nov-Dec;12(6):533-43. doi: 10.1080/03014468500008111.
Immunoglobulin (Gm and Km) allotype and haplotype frequencies are presented for 1707 individuals from Northern Chile and Western Bolivia, subdividing them by ethnicity and altitude of residence. The haplotype distribution of Gm as well as Km loci in these populations suggest that in almost all of the ethnicity x altitude subdivisions of this population considerable admixture of Amerindian and Caucasian genes have occurred. The haplotype frequency heterogeneity and the analysis of departure from Hardy-Weinberg expectations demonstrate that while some local variation in haplotype frequencies at the Gm and Km loci exists in this region, there is no clear evidence suggesting that the pattern of variation is due to an adaptation to the hypoxia of altitude. We conclude that such differences in haplotype frequencies are probably due to random genetic drift and differential admixture of Amerindian and Caucasian genes that have occurred in the past.
本文呈现了来自智利北部和玻利维亚西部的1707名个体的免疫球蛋白（Gm和Km）同种异型和单倍型频率，并按种族和居住海拔对他们进行了细分。这些人群中Gm以及Km位点的单倍型分布表明，在该人群几乎所有的种族×海拔细分群体中，美洲印第安人和高加索人的基因都发生了相当程度的混合。单倍型频率的异质性以及与哈迪-温伯格预期偏差的分析表明，虽然该区域Gm和Km位点的单倍型频率存在一些局部差异，但没有明确证据表明这种变异模式是由于对高原缺氧的适应。我们得出结论，这种单倍型频率的差异可能是由于过去发生的随机遗传漂变以及美洲印第安人和高加索人基因的不同混合所致。
