Saif Mohammad, Raza Mohammad Adnan, Patravale Vandana B
Rungta College of Pharmaceutical Sciences and Research, Bhilai, Chhattisgarh, 490023, India; Department of Pharmacy, Rungta International Skill University, Bhilai, Chhattisgarh, 490023, India.
Rungta College of Pharmaceutical Sciences and Research, Bhilai, Chhattisgarh, 490023, India; Department of Pharmacy, Rungta International Skill University, Bhilai, Chhattisgarh, 490023, India.
Int J Biol Macromol. 2025 Sep 5;327(Pt 2):147380. doi: 10.1016/j.ijbiomac.2025.147380.
Polysaccharide copolymers Conjuates have surfaced as a versatile foundation in the development of advanced smart drug delivery systems, owing to their inherent biocompatibility, biodegradability, and capacity for chemical modification. This review brings into focus the recent advances in co-polymeric drug delivery systems based on naturally occurring polysaccharides like chitosan, alginate, dextran, hyaluronic acid, pullulan, guar gum, xanthan gum, agarose, gellan gum, and starch. Their structural malleability and functionalization capabilities are emphasized to engineer therapeutic payload stability, bioavailability, and controlled release. The synthesis and design methods of Polysaccharide copolymeric conjugates are explained, coupled with advanced drug encapsulation techniques, conjugation, and surface modification approaches towards site-specific delivery. Mechanistic understanding of targeted delivery routes receptor-mediated targeting, tumor microenvironment responsiveness TMR, and pH/enzyme-sensitive release are discussed to exemplify the specificity and efficacy of these systems in oncology. The review explores the multifunctional applications of Polysaccharide copolymeric conjugates in cancer therapy, such as chemotherapy, gene and siRNA delivery, and immunotherapy. The advances in nanomedicine, especially in nanoparticle engineering, stimuli-responsive systems, and overcoming multidrug resistance MDR, are also discussed. By integrating the recent trends and innovations in Polysaccharide -based copolymeric drug delivery systems, in this article encapsulates the potential of these biopolymers as next-generation nanocarriers in targeted cancer treatment. The challenges and future directions in clinical translation are critically evaluated to steer future research towards more effective and safe therapeutic platforms.
多糖共聚物缀合物已成为先进智能药物递送系统开发中的一种通用基础，这归因于它们固有的生物相容性、生物可降解性以及化学修饰能力。本综述聚焦于基于壳聚糖、海藻酸盐、葡聚糖、透明质酸、支链淀粉、瓜尔豆胶、黄原胶、琼脂糖、结冷胶和淀粉等天然多糖的共聚物药物递送系统的最新进展。强调了它们的结构可塑性和功能化能力，以设计治疗性负载的稳定性、生物利用度和控释。解释了多糖共聚物缀合物的合成和设计方法，以及先进的药物包封技术、缀合和用于位点特异性递送的表面修饰方法。讨论了对靶向递送途径的机制理解，包括受体介导的靶向、肿瘤微环境响应性（TMR）和pH/酶敏感释放，以例证这些系统在肿瘤学中的特异性和有效性。本综述探讨了多糖共聚物缀合物在癌症治疗中的多功能应用，如化疗、基因和siRNA递送以及免疫疗法。还讨论了纳米医学的进展，特别是在纳米颗粒工程、刺激响应系统和克服多药耐药性（MDR）方面的进展。通过整合基于多糖的共聚物药物递送系统的最新趋势和创新，本文总结了这些生物聚合物作为下一代纳米载体在靶向癌症治疗中的潜力。对临床转化中的挑战和未来方向进行了批判性评估，以引导未来的研究朝着更有效和安全的治疗平台发展。
