Oishi S, Hiraga K
Toxicology. 1980;15(3):197-202. doi: 10.1016/0300-483x(80)90053-0.
Induction of testicular atrophy by monoesters of phthalic acid were compared in male Wistar rats. Dietary administration of monobutyl (MBP), mono-iso-butyl (MIBP) and mono-2-ethylhexyl phthalate (MEHP) induced severe atrophy of the testes. Furthermore, high testosterone concentration in the testes was found in MBP- and MIBP-treated rats, whereas low zinc concentration was found in MBP-, MIBP- and MEHP-treated rats. On the other hand, in monooctyl phthalate (MOP)-treated rats, testosterone and zinc concentrations in the testes were not changed. These were similar to the results with their diesters.
在雄性Wistar大鼠中比较了邻苯二甲酸单酯对睾丸萎缩的诱导作用。经口给予邻苯二甲酸单丁酯（MBP）、邻苯二甲酸单异丁酯（MIBP）和邻苯二甲酸单2-乙基己酯（MEHP）可导致睾丸严重萎缩。此外，在MBP和MIBP处理的大鼠睾丸中发现睾酮浓度较高，而在MBP、MIBP和MEHP处理的大鼠睾丸中发现锌浓度较低。另一方面，在邻苯二甲酸单辛酯（MOP）处理的大鼠中，睾丸中的睾酮和锌浓度没有变化。这些结果与它们的二酯的结果相似。
