Shen Xiedong, Tian Weiling, Xue Chun, Ji Xiangfuo, Qu Anqi, Lv Jun
Department of Vascular and Endovascular Surgery, The Second Affiliated Hospital of Naval University, Shanghai, China.
Interventional Radiology Department, The Second Affiliated Hospital of Naval University, Shanghai, China.
Front Nutr. 2025 Aug 21;12:1653773. doi: 10.3389/fnut.2025.1653773. eCollection 2025.
This study aims to investigate the impact of high-sodium diet (HSD) on the global burden of aortic aneurysm (AA), analyze its epidemiological trends across different regions, sexes, and age groups, and project future trends.
Data were obtained from the Global Burden of Disease Study 2021 (GBD 2021) to assess the disability-adjusted life years (DALYs) and death cases of AA attributable to HSD (AA-HSD) from 1990 to 2021. A decomposition analysis was conducted to quantify the contributions of population growth, aging, and epidemiological changes to the disease burden. The Nordpred model was used to project trends from 2022 to 2045.
From 1990 to 2021, the global DALYs cases of AA-HSD increased by 103%, and death cases increased by 120%. The largest increase in DALYs was observed in low-middle Socio-demographic Index (SDI) regions (234%), with South Asia experiencing the most significant rise (361%). Aging and population growth were the main drivers of the increased DALYs and death cases. While high SDI regions bore a heavier disease burden, relative inequality slightly improved. Projections indicate that from 2022 to 2045, both DALYs and death cases will continue to rise, with males experiencing a higher burden than females.
HSD significantly contribute to the global burden of AA, particularly in low-middle SDI regions. Moving forward, differentiated strategies should be adopted based on regional development levels, such as reinforcing salt-reduction policies, promoting early screening programs.
本研究旨在调查高钠饮食（HSD）对主动脉瘤（AA）全球负担的影响，分析其在不同地区、性别和年龄组中的流行病学趋势，并预测未来趋势。
数据来自《2021年全球疾病负担研究》（GBD 2021），以评估1990年至2021年归因于高钠饮食的主动脉瘤（AA-HSD）的伤残调整生命年（DALYs）和死亡病例。进行了分解分析，以量化人口增长、老龄化和流行病学变化对疾病负担的贡献。使用Nordpred模型预测2022年至2045年的趋势。
1990年至2021年，全球AA-HSD的DALYs病例增加了103%，死亡病例增加了120%。在社会人口指数（SDI）较低的中等地区观察到DALYs增加幅度最大（234%），其中南亚增长最为显著（361%）。老龄化和人口增长是DALYs和死亡病例增加的主要驱动因素。虽然高SDI地区的疾病负担较重，但相对不平等略有改善。预测表明，从2022年到2045年，DALYs和死亡病例都将继续上升，男性的负担高于女性。
高钠饮食对全球主动脉瘤负担有显著贡献，尤其是在社会人口指数较低的中等地区。未来，应根据区域发展水平采取差异化策略，如加强减盐政策、推广早期筛查项目。
