Yang Yapan, Tu Runqi, Zhu Lijie, Xu Guian, Yang Tingjie, Li Qingman, Wang Che, Yang Honghui
Department of Cardiology, Central China Fuwai Hospital, Central China Fuwai Hospital of Zhengzhou University, Henan Provincial People's Hospital Heart Center, Zhengzhou, Henan, China.
Department of Cardiology, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Exp Biol Med (Maywood). 2025 Aug 21;250:10704. doi: 10.3389/ebm.2025.10704. eCollection 2025.
The relationship between the systemic immune-inflammation index (SII) and the risk of developing cardiovascular disease (CVD) over the next 10 years in the United States is largely unknown. The aim of this study is to assess the association between SII and 10-year CVD risk. This population-based cross-sectional study included 9901 participants aged between 30 and 74 from the National Health and Nutrition Examination Survey (NHANES) 1999-2018. The 10-year CVD risk was calculated using the Framingham cardiovascular risk score (FRS). The Pearson test, generalized linear model (GLM) and restricted cubic splines (RCS) were used to analyze the associations between SII and the FRS. Based on the total population, the Pearson test and GLM revealed that there were positive relationships between Ln-transformed SII (Ln (SII)) and the FRS. After adjusting for confounding factors, the odds ratio (OR) for the FRS was 1.52 (95% confidence interval [CI]: 1.12-2.06) per unit increment in Ln (SII) ( = 0.009). Compared to the lowest quartile (Q1) of Ln (SII), the OR for the FRS in the highest quartile (Q4) was 1.89 (95% CI: 1.20-2.98; = 0.007). RCS revealed that there was a linear association between Ln (SII) and the FRS ( for non-linearity = 0.972). As Ln (SII) increased, the value of FRS rose gradually ( for overall trend <0.001). However, the relationship between Ln (SII) and FRS showed ethnic heterogeneity. In conclusion, SII exhibits significant associations with 10-year CVD risk as assessed by the FRS. However, this association varies across ethnic groups, necessitating cautious application and further validation.
在美国，全身免疫炎症指数（SII）与未来10年发生心血管疾病（CVD）风险之间的关系在很大程度上尚不清楚。本研究的目的是评估SII与10年CVD风险之间的关联。这项基于人群的横断面研究纳入了1999 - 2018年美国国家健康与营养检查调查（NHANES）中9901名年龄在30至74岁之间的参与者。使用弗雷明汉心血管风险评分（FRS）计算10年CVD风险。采用Pearson检验、广义线性模型（GLM）和受限立方样条（RCS）分析SII与FRS之间的关联。基于总体人群，Pearson检验和GLM显示，经Ln转换的SII（Ln（SII））与FRS之间存在正相关关系。在调整混杂因素后，Ln（SII）每增加一个单位，FRS的比值比（OR）为1.52（95%置信区间[CI]：1.12 - 2.06）（P = 0.009）。与Ln（SII）的最低四分位数（Q1）相比，最高四分位数（Q4）的FRS的OR为1.89（95% CI：1.20 - 2.98；P = 0.007）。RCS显示Ln（SII）与FRS之间存在线性关联（非线性检验P = 0.972）。随着Ln（SII）增加，FRS值逐渐上升（总体趋势检验P <0.001）。然而，Ln（SII）与FRS之间的关系存在种族异质性。总之，通过FRS评估，SII与10年CVD风险存在显著关联。然而，这种关联在不同种族群体中有所不同，需要谨慎应用并进一步验证。
