Cell bank system, establishment, and application in the virus research, diagnosis, and biopharmaceutical industries.

BACKGROUND

The use of cells in research and diagnostic studies is important. This is of paramount importance in the biopharmaceutical product industry because cells are one of the most important platforms in the biopharmaceutical industry.

OBJECTIVE

The availability of highly efficient and suitable cells that can be continuously used for the mass production of biotechnological products is crucial for maintaining human health and hygiene. So, the cells used in this comprehensive system were studied, evaluated, documented, and stored for continuous and efficient use.

STUDY DESIGN

This review article discusses all aspects of cells involved in establishing this system as a Cell Bank System (CBS). Cell banking facilities, specialized laboratories, appropriate equipment, cold rooms, cryopreservation instruments, and cell authentication and characterization are mentioned. Cell handling, row materials tests, documentation, intellectual property registration, storage, backup, and transportation were explained. In addition, policies for cell retesting and revival are discussed.

RESULT

Based on the roadmap designed in this study, a comprehensive cell bank system can be formed for using in cell preparation, propagation, storage, and use of cells.

DISCUSSION

Considering that in the pharmaceutical industry, there is a need for a reliable, permanent, and uniform source of cells to produce and quality control the product, which can have significant effects on the products, by using this system and performing all of its aspects, diagnostic centers, researchers, and pharmaceutical manufacturers can access a reliable and persistent source of culture for related operations.