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通过共振量子隧穿实现的表面等离子体生物传感器。

Plasmonic biosensor enabled by resonant quantum tunnelling.

作者信息

Lee Jihye, Wu Yina, Sinev Ivan, Masharin Mikhail, Papadopoulos Sotirios, Dias Eduardo J C, Wang Lujun, Tseng Ming Lun, Moon Seunghwan, Yeo Jong-Souk, Novotny Lukas, García de Abajo F Javier, Altug Hatice

机构信息

Institute of Bioengineering, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.

ICFO-Institut de Ciencies Fotoniques, The Barcelona Institute of Science and Technology, Castelldefels, Spain.

出版信息

Nat Photonics. 2025;19(9):938-945. doi: 10.1038/s41566-025-01708-y. Epub 2025 Jun 26.

Abstract

Metasurfaces provide an ideal platform for optical sensing because they produce strong light-field confinement and enhancement over extended regions that allow us to identify deep-subwavelength layers of organic and inorganic molecules. However, the requirement of using external light sources involves bulky equipment that hinders point-of-care applications. Here we introduce a plasmonic sensor with an embedded source of light provided by quantum tunnel junctions. An optically resonant, doubly periodic nanowire metasurface serves as a top contact for the junction and provides extremely uniform emission over large areas, amplified by plasmonic nanoantenna modes that simultaneously enhance the spectral and refractive index sensitivity. As a proof of concept, we demonstrate spatially resolved refractometric sensing of nanometre-thick polymer and biomolecule coatings. Our results open exciting prospects based on a disruptive platform for integrated electro-optical biosensors.

摘要

超表面为光学传感提供了一个理想平台,因为它们能在扩展区域产生强光场限制和增强,使我们能够识别有机和无机分子的深亚波长层。然而,使用外部光源的要求涉及笨重的设备,这阻碍了即时护理应用。在此,我们介绍一种具有由量子隧道结提供的嵌入式光源的等离子体传感器。一个光学谐振的双周期纳米线超表面用作结的顶部接触,并在大面积上提供极其均匀的发射,由等离子体纳米天线模式放大,同时增强光谱和折射率灵敏度。作为概念验证,我们展示了对纳米厚聚合物和生物分子涂层的空间分辨折射传感。我们的结果基于一个用于集成电光生物传感器的颠覆性平台开启了令人兴奋的前景。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4890/12411226/792cb4c5e4cc/41566_2025_1708_Fig1_HTML.jpg

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