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巴西散养产蓝蛋的凯皮拉鸡MHC II类B-Lβ基因的免疫遗传多样性

Immunogenetic diversity of MHC class II B-Lβ genes in Brazilian Caipiras (free-range) chickens laying blue eggs.

作者信息

Costamilan Carlos André da Veiga Lima Rosa, Paludo Ediane, Herkenhoff Marcos Edgar, Pértille Fábio, de Souza André Luigi Soares, Mendes Carolina Rosai, Dilarri Guilherme

机构信息

Department of Fisheries Engineering and Biological Sciences, Santa Catarina State University (UDESC), Laguna, Santa Catarina, Brazil.

Institute of Improvement and Molecular Genetics (IMEGEM), Santa Catarina State University (UDESC), Lages, Santa Catarina, Brazil.

出版信息

Front Immunol. 2025 Aug 21;16:1644110. doi: 10.3389/fimmu.2025.1644110. eCollection 2025.

DOI:10.3389/fimmu.2025.1644110
PMID:40918105
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12408319/
Abstract

INTRODUCTION

Brazilian Caipira chickens that lay blue eggs are known to possess unique genetic traits. This study investigates the immunogenetic diversity of MHC class II B-Lβ genes (B-LβI and B-LβII) in this population, aiming to assess their potential value in selective breeding programs focused on disease resistance.

MATERIAL AND METHODS

A total of 100 chickens were analyzed using targeted sequencing of the B-LβI and B-LβII genes. The resulting nucleotide sequences were evaluated for polymorphism and compared with known alleles described in previous studies.

RESULTS

Fifteen unique nucleotide sequences were identified, of which five had not been previously reported in the scientific literature. The new alleles exhibited significant polymorphism, confirming high genetic diversity within the population.

DISCUSSION

The genetic variability observed supports earlier findings regarding the diversity of MHC genes in local chicken breeds. These novel alleles may confer advantages in immune responsiveness, reinforcing the importance of preserving local breeds as reservoirs of functional genetic diversity.

CONCLUSION

Brazilian Caipira chickens laying blue eggs display remarkable immunogenetic diversity in MHC class II B-L β genes. This variation includes novel alleles with potential application in future breeding programs. Conservation and utilization of this genetic resource can contribute to the development of healthier and more disease-resistant commercial chicken lines.

摘要

引言

已知产蓝蛋的巴西卡皮拉鸡具有独特的遗传特性。本研究调查了该种群中MHC II类B-Lβ基因（B-LβI和B-LβII）的免疫遗传多样性，旨在评估它们在以抗病性为重点的选择性育种计划中的潜在价值。

材料与方法

使用B-LβI和B-LβII基因的靶向测序对总共100只鸡进行分析。对所得核苷酸序列进行多态性评估，并与先前研究中描述的已知等位基因进行比较。

结果

鉴定出15个独特的核苷酸序列，其中5个在科学文献中未曾报道过。新等位基因表现出显著的多态性，证实了该种群内的高遗传多样性。

讨论

观察到的遗传变异性支持了先前关于本地鸡品种中MHC基因多样性的研究结果。这些新等位基因可能在免疫反应性方面具有优势，强化了将本地品种作为功能性遗传多样性库加以保护的重要性。

结论

产蓝蛋的巴西卡皮拉鸡在MHC II类B-Lβ基因中表现出显著的免疫遗传多样性。这种变异包括在未来育种计划中具有潜在应用价值的新等位基因。保护和利用这一遗传资源有助于培育更健康、抗病能力更强的商业鸡品系。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2958/12408319/8f466223e614/fimmu-16-1644110-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2958/12408319/60e960a9872d/fimmu-16-1644110-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2958/12408319/a0c2e9d2c4c7/fimmu-16-1644110-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2958/12408319/327145e528ae/fimmu-16-1644110-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2958/12408319/91a0b3cddbb2/fimmu-16-1644110-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2958/12408319/8f466223e614/fimmu-16-1644110-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2958/12408319/60e960a9872d/fimmu-16-1644110-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2958/12408319/a0c2e9d2c4c7/fimmu-16-1644110-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2958/12408319/327145e528ae/fimmu-16-1644110-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2958/12408319/91a0b3cddbb2/fimmu-16-1644110-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2958/12408319/8f466223e614/fimmu-16-1644110-g005.jpg

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Identification and bioinformatic analysis of invA gene of Salmonella in free range chicken.鉴定并生物信息学分析散养鸡肉中沙门氏菌的 invA 基因。
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Genetic diversity and signatures of selection for heat tolerance and immune response in Iranian native chickens.伊朗本土鸡的耐热性和免疫反应的遗传多样性和选择特征。
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