İritaş Seçil Yigen, İritaş İlter, Saritaş Zülfükar Kadir, Görücü Fatma, Demirel H Hüseyin, Bülbül Aziz, Koç Yusuf
From the Department of Dermatology and Venerology, Pendik State Hospital, Istanbul, Turkey.
Department of Ophthalmology, Pendik State Hospital, Istanbul, Turkey.
Indian J Dermatol. 2025 Sep-Oct;70(5):275-282. doi: 10.4103/ijd.ijd_177_24. Epub 2025 Sep 1.
It is known that quercetin is useful in the treatment of pressure wounds due to its ability to reduce oxygen radicals, but its effect on eyelid wound healing is unclear. In this study, forty male Wistar albino rats weighing 250-300 grams were used to investigate the effect of quercetin on eyelid wound healing. Four groups were created: control group, sham group, incision wound group, and suture + quercetin group. Full-thickness skin excision was performed through a 3-5 mm incision in the superior palpebrae to create a wound. On the 1 third and seventh days, the rats were sacrificed, and blood samples were taken by cardiac puncture for biochemical measurement and tissue samples for histopathological examination from the palpebrae. 2 Inflammatory cells in the quercetin group were significantly lower on day 3 ( < 0.05). Blood levels of IL-1 and TNF-α were significantly lower in the quercetin group compared to other groups ( < 0.05). Also, IL-6 was found to be significantly lower on day 7 in the quercetin group compared to other groups ( < 0.05). The quercetin group was as effective as the sham group in terms of collagen formation on day 3, and the hydroxyproline value was significantly higher. Total oxidant status levels were lower in the quercetin group than in the sham group ( = 0.005). In conclusion, quercetin exhibited anti-inflammatory and antioxidant effects, along with higher collagen accumulation in the eyelid compared to other groups. Our results suggest that quercetin could be a potential therapeutic agent that accelerates wound healing and reduces scar formation in the eyelid.
已知槲皮素因其具有减少氧自由基的能力而对治疗压疮有益，但其对眼睑伤口愈合的影响尚不清楚。在本研究中，使用了40只体重为250 - 300克的雄性Wistar白化大鼠来研究槲皮素对眼睑伤口愈合的影响。创建了四组：对照组、假手术组、切口伤口组和缝合 + 槲皮素组。通过在上睑进行3 - 5毫米的切口进行全层皮肤切除以形成伤口。在第3天和第7天，处死大鼠，通过心脏穿刺采集血样进行生化测量，并从眼睑采集组织样本进行组织病理学检查。2槲皮素组在第3天的炎症细胞明显较少（<0.05）。与其他组相比，槲皮素组的IL - 1和TNF - α血液水平明显较低（<0.05）。此外，与其他组相比，槲皮素组在第7天的IL - 6明显较低（<0.05）。在第3天，槲皮素组在胶原蛋白形成方面与假手术组一样有效，且羟脯氨酸值明显更高。槲皮素组的总氧化剂状态水平低于假手术组（=0.005）。总之，槲皮素表现出抗炎和抗氧化作用，并且与其他组相比，其在眼睑中的胶原蛋白积累更高。我们的结果表明，槲皮素可能是一种潜在的治疗剂，可加速伤口愈合并减少眼睑瘢痕形成。
