School of Life Science and Biotechnology, Dalian University of Technology, Dalian 116024, China.
Biomed Res Int. 2013;2013:754802. doi: 10.1155/2013/754802. Epub 2013 Jan 20.
Impaired diabetic wound healing constitutes a major health problem. The impaired healing is caused by complex factors such as abnormal keratinocyte and fibroblast migration, proliferation, differentiation, and apoptosis, abnormal macrophage polarization, impaired recruitment of mesenchymal stem cells (MSCs) and endothelial progenitor cells (EPCs), and decreased vascularization. Diabetes-enhanced and prolonged expression of TNF- α also contributes to impaired healing. In this paper, we discuss the abnormal cell responses in diabetic wound healing and the contribution of TNF- α .
糖尿病患者的伤口愈合受损是一个主要的健康问题。这种愈合受损是由多种复杂因素引起的，如角质形成细胞和成纤维细胞的迁移、增殖、分化和凋亡异常，巨噬细胞极化异常，间充质干细胞（MSCs）和内皮祖细胞（EPCs）募集受损，以及血管生成减少。糖尿病增强和延长 TNF-α 的表达也会导致愈合受损。本文讨论了糖尿病伤口愈合中异常的细胞反应以及 TNF-α 的作用。
