Ziaieardestani Bijan, Kolebaba Brenda, Hauck Carmel, Naserli Soulmaz
St. Vital Veterinary Hospital, Winnipeg, Manitoba (Ziaieardestani, Kolebaba, Hauck); Department of Animal Science, Faculty of Agriculture and Food Sciences, University of Manitoba, Winnipeg, Manitoba (Naserli).
Can Vet J. 2025 Aug 1;66(8):843-846. eCollection 2025 Aug.
Feline demodicosis is a rare parasitic skin disease. The clinical signs, which may range from mild and localized to severe and generalized, include alopecia, erythema, macules, pruritus, and hyperpigmentation. Although many studies have evaluated the safety and efficacy of different miticidal agents for canine demodicosis, there have been no controlled or conclusive studies on feline infection. Recommended medications for cats include organophosphates, lime sulfur, some macrocylic lactones, and isoxazolines, which may be administered as rinse, injection, oral or spot-on formulations. Most of these treatments are poorly tolerated by cats and have been associated with some adverse effects leading to treatment failure. Isoxazolines including sarolaner and fluralaner were introduced to veterinary medicine in 2014 and have gained remarkable popularity due to the rare occurrence of side effects with these treatments. However, literature reviews reveal only a few published reports of the effectiveness of this medication class on infestation in cats. To the authors' knowledge, this case report documents the first successful treatment of the generalized form of demodicosis caused by in a cat achieved with 2 monthly doses of topical application of sarolaner-selamectin combination. This may be a useful reference for practitioners. Key clinical message: There is no consensus on an ideal treatment for feline demodicosis due to lack of published data in cats. This report provides support for sarolaner/selamectin spot-on treatment (Revolution Plus; Zoetis) as an effective, safe, and practical treatment for mange in cats.
猫蠕形螨病是一种罕见的寄生虫性皮肤病。其临床症状范围从轻度局部到重度全身性，包括脱毛、红斑、斑疹、瘙痒和色素沉着。尽管许多研究评估了不同杀螨剂对犬蠕形螨病的安全性和有效性，但对于猫感染却没有对照或结论性研究。推荐给猫使用的药物包括有机磷酸盐、石硫合剂、一些大环内酯类药物和异恶唑啉类药物，这些药物可以以冲洗液、注射剂、口服制剂或滴剂的形式给药。大多数这些治疗方法猫的耐受性较差，并伴有一些不良反应，导致治疗失败。包括沙罗拉纳和氟拉纳在内的异恶唑啉类药物于2014年引入兽医学，由于这些治疗方法副作用罕见，因此广受欢迎。然而，文献综述显示，关于这类药物对猫感染有效性的已发表报告很少。据作者所知，本病例报告记录了第一例通过每月局部应用两次沙罗拉纳-塞拉菌素组合成功治疗猫全身性蠕形螨病的病例。这可能为从业者提供有用的参考。关键临床信息：由于缺乏关于猫的已发表数据，对于猫蠕形螨病的理想治疗方法尚无共识。本报告支持将沙罗拉纳/塞拉菌素滴剂（瑞倍亮Plus；硕腾公司）作为治疗猫疥螨病的一种有效、安全且实用的方法。
