Department of Obstetrics & Gynecology, Yonsei University Wonju College of Medicine, Wonju, Korea.
Department of Laboratory Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea.
Ann Lab Med. 2021 Jul 1;41(4):380-385. doi: 10.3343/alm.2021.41.4.380.
Although group B (GBS) colonization rate among pregnant Korean women is lower than that among women from many Western countries, recent data show an upward trend. We investigated recent epidemiological changes in GBS among pregnant Korean women in terms of colonization rate, antimicrobial susceptibility, serotype, and resistance genotype.
Vaginal and anorectal swab specimens from 379 pregnant Korean women were cultured on Strep B Carrot Broth with GBS Detect (Hardy Diagnostics, USA), selective Todd-Hewitt broth (Becton Dickinson, USA), and Granada agar plate medium (Becton Dickinson). The antimicrobial susceptibility, serotypes, and macrolide-lincosamide-streptogramin B (MLSB) resistance genes of the GBS isolates were tested.
The GBS colonization rate among pregnant Korean women was 19.8% (75/379). Colonization rates using Strep B Carrot Broth with GBS Detect, selective Todd-Hewitt broth, and Granada agar plate medium cultures were 19.5%, 19.3%, and 15.0%, respectively. Six pregnant women were colonized by non-beta-hemolytic GBS and were detected only in Strep B Carrot Broth with GBS Detect. Resistance rates of GBS to clindamycin, erythromycin, and tetracycline were 16.0%, 28.0%, and 42.7%, respectively. The most common GBS serotypes were V (22.7%), VIII (20.0%), and III (20.0%). The frequency of MLSB resistance genes (B) and (TR) were 63.6% and 36.4%, respectively.
The GBS colonization rate among pregnant Korean women has risen to levels observed in Western countries. To accurately evaluate GBS epidemiology among pregnant Korean women, periodic studies in multiple centers, including primary clinics, are necessary.
尽管韩国孕妇的 B 群链球菌（GBS）定植率低于许多西方国家的女性，但最近的数据显示出上升趋势。我们调查了最近韩国孕妇中 GBS 的流行病学变化，包括定植率、抗菌药物敏感性、血清型和耐药基因型。
采集 379 名韩国孕妇的阴道和直肠拭子标本，分别在 GBS 检测（Hardy Diagnostics，美国）的 Strep B 胡萝卜肉汤、选择性 Todd-Hewitt 肉汤（Becton Dickinson，美国）和 Granada 琼脂平板培养基（Becton Dickinson）上进行培养。对 GBS 分离株的抗菌药物敏感性、血清型和大环内酯-林可酰胺-链阳菌素 B（MLSB）耐药基因进行检测。
韩国孕妇的 GBS 定植率为 19.8%（75/379）。使用 GBS 检测的 Strep B 胡萝卜肉汤、选择性 Todd-Hewitt 肉汤和 Granada 琼脂平板培养基培养的定植率分别为 19.5%、19.3%和 15.0%。有 6 名孕妇被非β-溶血性 GBS 定植，仅在 GBS 检测的 Strep B 胡萝卜肉汤中检测到。GBS 对克林霉素、红霉素和四环素的耐药率分别为 16.0%、28.0%和 42.7%。最常见的 GBS 血清型为 V（22.7%）、VIII（20.0%）和 III（20.0%）。MLSB 耐药基因（B）和（TR）的频率分别为 63.6%和 36.4%。
韩国孕妇的 GBS 定植率已上升至西方国家的水平。为了准确评估韩国孕妇的 GBS 流行病学，有必要在包括基层诊所在内的多个中心进行定期研究。
