Suppr超能文献

与真性髋关节发育不良相比,边缘性髋关节发育不良患者的患者报告结局较差。

Patients with borderline hip dysplasia present with inferior patient-reported outcomes compared to true hip dysplasia.

作者信息

Karisch Quentin, Haertlé Marco, Stamp Justus, Ramadanov Nikolai, Windhagen Henning, Ahmad Sufian S

机构信息

Department of Orthopedic Surgery, Hannover Medical School Diakovere Annastift Hannover Germany.

Center of Orthopedics and Traumatology, Brandenburg Medical School University Hospital Brandenburg an der Havel Brandenburg an der Havel Germany.

出版信息

J Exp Orthop. 2025 Sep 4;12(3):e70407. doi: 10.1002/jeo2.70407. eCollection 2025 Jul.

Abstract

PURPOSE

The factors influencing patient-reported outcome measures (PROMs) in individuals with developmental dysplasia of the hip (DDH) remain poorly understood. The aim of this study was to determine the differences in hip-related PROMs in both borderline and true hip dysplasia.

METHODS

A total of 245 patients with symptomatic DDH were enrolled. Hips were divided into either borderline dysplasia (lateral centre-edge angle [LCEA] 20°-25°) or true dysplasia (LCEA < 20°). PROMs were retrieved from all patients. Linear regression analysis was performed to identify potential factors associated with PROMs. The relationship between PROMs and the characteristic of dysplasia and between patients with DDH and healthy people was assessed.

RESULTS

Patients with borderline hip dysplasia had significantly poorer scores compared to true dysplasia on the University of California and Los Angeles activity scale (UCLA), the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), the Merle d'Aubigné and postel score and the German forgotten joint score (G-FJS). In patients with DDH, all PROMs were significantly lower compared to the control group. In patients with true dysplasia, body mass index (BMI) emerged as the most influential factor affecting the hip disability and osteoarthritis outcome score-physical function shortform (HOOS-PS), WOMAC, International Hip Outcome Tool 12 (iHOT-12) and Harris hip score (HHS). In contrast, in patients with borderline dysplasia, radiographic parameters such as anterior wall coverage significantly influenced the WOMAC, iHOT-12, HHS, modified HHS and G-FJS, while the LCEA was associated with UCLA and HOOS-PS scores. Age was identified as a significant predictor in borderline dysplasia.

CONCLUSION

Patients with borderline dysplasia report poorer PROMs compared to true dysplasia, suggesting a distinct clinical and diagnostic burden in this group of patients. Moreover, the increased mechanical load associated with higher BMI appears to play a greater role only in patients with true dysplasia.

LEVEL OF EVIDENCE

Level III.

摘要

目的

影响发育性髋关节发育不良(DDH)患者报告结局量表(PROMs)的因素仍未得到充分了解。本研究的目的是确定临界性和真性髋关节发育不良患者髋关节相关PROMs的差异。

方法

共纳入245例有症状的DDH患者。髋关节被分为临界发育不良(外侧中心边缘角[LCEA]20°-25°)或真性发育不良(LCEA<20°)。收集所有患者的PROMs。进行线性回归分析以确定与PROMs相关的潜在因素。评估PROMs与发育不良特征之间以及DDH患者与健康人之间的关系。

结果

在加利福尼亚大学洛杉矶分校活动量表(UCLA)、西安大略和麦克马斯特大学骨关节炎指数(WOMAC)、Merle d'Aubigné和Postel评分以及德国遗忘关节评分(G-FJS)方面,临界性髋关节发育不良患者的得分明显低于真性发育不良患者。在DDH患者中,所有PROMs均显著低于对照组。在真性发育不良患者中,体重指数(BMI)成为影响髋关节残疾和骨关节炎结局评分-身体功能简表(HOOS-PS)、WOMAC、国际髋关节结局工具12(iHOT-12)和Harris髋关节评分(HHS)的最有影响因素。相比之下,在临界发育不良患者中,诸如前壁覆盖等影像学参数显著影响WOMAC、iHOT-12、HHS、改良HHS和G-FJS,而LCEA与UCLA和HOOS-PS评分相关。年龄被确定为临界发育不良的一个重要预测因素。

结论

与真性发育不良相比,临界发育不良患者报告的PROMs较差,这表明该组患者有独特的临床和诊断负担。此外,与较高BMI相关的机械负荷增加似乎仅在真性发育不良患者中起更大作用。

证据水平

三级。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa05/12409825/92ae2074aec0/JEO2-12-e70407-g002.jpg

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验