关于细胞粘附分子对囊泡的粘附作用。
On the adhesion of vesicles by cell adhesion molecules.
作者信息
Bell G I, Torney D C
出版信息
Biophys J. 1985 Dec;48(6):939-47. doi: 10.1016/S0006-3495(85)83857-1.
Abstract
This paper gives a detailed analysis of experiments on the kinetics of aggregation of lipid vesicles containing neural cell adhesion molecules (N-CAM). An explanation for the dependence of the "initial aggregation rate," kagg, on the square of the vesicle concentration is given, accounting both for Brownian motion of the vesicles and shear effects. A model in which trimers of N-CAM are one-half of the molecular unit bridging two vesicles explains the observed dependence of kagg on up to the sixth power of the lateral N-CAM concentration and corroborates electron micrographic evidence for N-CAM "triskelions."
摘要
本文详细分析了含有神经细胞黏附分子（N-CAM）的脂质囊泡聚集动力学实验。给出了“初始聚集速率”kagg对囊泡浓度平方依赖性的解释，同时考虑了囊泡的布朗运动和剪切效应。一个模型表明，N-CAM三聚体是连接两个囊泡的分子单元的一半，该模型解释了观察到的kagg对横向N-CAM浓度六次方的依赖性，并证实了N-CAM“三叉戟”的电子显微镜证据。
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本文引用的文献
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Localization of cell membrane components by surface diffusion into a "trap".通过表面扩散至“陷阱”实现细胞膜成分的定位
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Developmental biology of a neural cell adhesion molecule.一种神经细胞黏附分子的发育生物学
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Molecular topography of the neural cell adhesion molecule N-CAM: surface orientation and location of sialic acid-rich and binding regions.神经细胞黏附分子N-CAM的分子拓扑结构：富含唾液酸区域和结合区域的表面取向与定位
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Fc receptor modulation in mononuclear phagocytes maintained on immobilized immune complexes occurs by diffusion of the receptor molecule.固定化免疫复合物上维持的单核吞噬细胞中Fc受体的调节是通过受体分子的扩散发生的。
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