老年多病患者的用药多重体验：一项质性元整合研究
Medication multiple experiences of elderly patient with multiple chronic condition: A qualitative meta-synthesis.
作者信息
Xin Guo, Yuanxing Wang, Jiaming Wu, Xue Hu
机构信息
School of Nursing, Yunnan University of Chinese Medicine, Kunming City, Yunnan Province, China.
Faculty of Sociology, Lomonosov Moscow State University, Moscow city, Russia.
出版信息
PLoS One. 2025 Sep 9;20(9):e0331753. doi: 10.1371/journal.pone.0331753. eCollection 2025.
PURPOSE
To determine the experience of medication multiple in elderly patients with multiple chronic condition by systematically reviewing, retrieving, and synthesizing data from qualitative studies.
METHODS
Nine databases were systematically searched for relevant contributions from the time of construction until October 30, 2024. All qualitative studies in English and Chinese exploring the real-life experiences, feelings, etc, of medication multiple in elderly patients with multiple chronic condition were included. The Enhancing Transparency in Reporting the Synthesis of Qualitative Research (ENTREQ).Two independent reviewers selected the studies and assessed the quality of each study, and the included studies were inductively analysed and interpreted then reported as a meta-synthesis.
RESULTS
A total of 10 studies revealed 13 sub-themes and 4 descriptive themes:Difficulties and challenges in Polypharmacy, Multi-party support facilitates Polypharmacy in elderly patients with multiple chronic condition,Positive attitude towards taking medication.
CONCLUSION
The health outcomes of elderly patients with coexisting chronic diseases can be significantly impacted by polypharmacy difficulties and challenges as well as lower medication adherence.Increasing medicine knowledge among older patients with concomitant chronic diseases, bolstering medication-taking beliefs, and motivating family members to support the patient are all ways to improve medication adherence. [REGISTRATION: PROSPERO ID: CRD42024628547].
目的
通过系统回顾、检索和综合定性研究数据，确定老年慢性病患者多重用药的经历。
方法
系统检索九个数据库，查找自建库至2024年10月30日的相关文献。纳入所有探讨老年慢性病患者多重用药现实生活经历、感受等的中英文定性研究。采用提高定性研究综合报告透明度（ENTREQ）方法。两名独立评审员筛选研究并评估每项研究的质量，对纳入研究进行归纳分析和解释，然后作为元综合报告呈现。
结果
共10项研究揭示了13个子主题和4个描述性主题：多重用药的困难与挑战、多方支持促进老年慢性病患者多重用药、对服药的积极态度。
结论
多重用药的困难与挑战以及较低的服药依从性会显著影响老年慢性病共存患者的健康结局。增加老年慢性病患者的用药知识（原文为medicine knowledge，此处似应为medication knowledge）、增强服药信念以及激励家庭成员支持患者，都是提高服药依从性的方法。[注册：PROSPERO编号：CRD42024628547]
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