Olaizola Iurre, Ochoa de Retana Ana María, de Los Santos Jesús M
Department of Organic Chemistry I, Faculty of Pharmacy and Lascaray Research Center, University of the Basque Country (UPV/EHU), Paseo de La Universidad 7, 01006, Vitoria-Gasteiz, Spain.
Top Curr Chem (Cham). 2025 Sep 10;383(4):40. doi: 10.1007/s41061-025-00519-7.
Aziridines, structurally related to epoxides, are among the most challenging and fascinating heterocycles in organic chemistry due to their increasing applications in asymmetric synthesis, medicinal chemistry, and materials science. These three-membered nitrogen-containing rings serve as key intermediates in the synthesis of chiral amines, complex molecules, and pharmaceutically relevant compounds. This review provides an overview of recent progress in catalytic asymmetric aziridination, focusing on novel methodologies, an analysis of the scope and limitations of each approach, and mechanistic insights.
氮丙啶在结构上与环氧化物相关，由于其在不对称合成、药物化学和材料科学中日益广泛的应用，成为有机化学中最具挑战性和吸引力的杂环化合物之一。这些含氮的三元环在手性胺、复杂分子和药物相关化合物的合成中作为关键中间体。本文综述了催化不对称氮丙啶化反应的最新进展，重点介绍了新方法、每种方法的适用范围和局限性分析以及机理见解。
