Wu Binghuo, Song Fei, Han Xue, Zhao Minyi, Huang Meijia, Zhang Wenwen, Tan Tian, Gong Yanju, Cao Chenhui, Cheng Songtao
Institute of Blood Transfusion, Chinese Academy of Medical Sciences & Peking Union Medical College (CAMS & PUMC), Chengdu, China.
Department of Urology, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.
Ann Med. 2025 Dec;57(1):2557507. doi: 10.1080/07853890.2025.2557507. Epub 2025 Sep 9.
This study provides a comprehensive analysis of the global, regional, and national epidemiology of acute myeloid leukemia (AML) from 1990 to 2021, focusing on incidence, mortality, and disability-adjusted life years (DALYs).
Using data from the Global Burden of Disease (GBD) study, we investigated the trends and patterns of AML across 204 countries and territories during 1990 to 2021. All statistical analyses and data visualizations were performed using R (version 4.4.2) and JD_GBDR (V2.36).
The global incidence of AML increased by 82.25% from 79.37 × 10³ cases in 1990 to 144.65 × 10³ cases in 2021, with significant variations across regions. AML-related deaths increased by 73.77% globally, from 74.92 × 10³ in 1990 to 130.19 × 10³ in 2021. DALYs rose by 23.70%, from 3342.91 × 10³ in 1990 to 4135.06 × 10³ in 2021.
High SDI regions face higher incidence and mortality due to advanced diagnostics and aging, while low-middle SDI regions show rapid increases likely due to urbanization and lifestyle changes. Addressing these disparities requires improved healthcare infrastructure, early detection, and targeted interventions, particularly in low- and middle-income countries (LMICs).
本研究全面分析了1990年至2021年全球、区域和国家急性髓系白血病（AML）的流行病学情况，重点关注发病率、死亡率和伤残调整生命年（DALYs）。
利用全球疾病负担（GBD）研究的数据，我们调查了1990年至2021年期间204个国家和地区的AML趋势和模式。所有统计分析和数据可视化均使用R（版本4.4.2）和JD_GBDR（V2.36）进行。
全球AML发病率从1990年的79.37×10³例增加到2021年的144.65×10³例，增长了82.25%，各地区差异显著。全球与AML相关的死亡人数从1990年的74.92×10³例增加到2021年的130.19×10³例，增长了73.77%。伤残调整生命年增加了23.70%，从1990年的3342.91×10³增加到2021年的4135.06×10³。
高社会人口指数（SDI）地区由于先进的诊断技术和老龄化面临更高的发病率和死亡率，而中低SDI地区由于城市化和生活方式的改变呈现快速增长。解决这些差异需要改善医疗基础设施、早期检测和有针对性的干预措施，特别是在低收入和中等收入国家（LMICs）。
