Sizova Elena A, Shoshin Daniil E, Yausheva Elena V, Ivanishcheva Anastasia P, Nechitailo Ksenia S, Ryazantseva Kristina V
Federal Research Centre of Biological Systems and Agrotechnologies of the Russian Academy of Sciences, 29, 9 Yanvarya Street, Orenburg, 460000, Russia.
Scientific Educational Center "Biological Systems and Nanotechnologies", Orenburg State University, 13, Pobedy Avenue, Orenburg, 460018, Russia.
Vet World. 2025 Jul;18(7):2095-2105. doi: 10.14202/vetworld.2025.2095-2105. Epub 2025 Jul 30.
The global demand for efficient poultry production necessitates alternatives to antibiotic growth promoters. This study aimed to evaluate the effects of a novel four-component organic-mineral feed additive (OMFA), comprising lactulose, arginine, ultrafine silicon dioxide particles, and succinic acid, and a three-component variant (without lactulose) on growth performance, nutrient digestibility, elemental tissue composition, and the cecal microbiota of Arbor Acres broiler chickens.
One hundred and five one-day-old broiler chicks were randomly allocated into three groups: Control, Group I (four-component OMFA), and Group II (three-component OMFA). Growth metrics were recorded weekly over a 42-day period. Nutrient digestibility was assessed through balance experiments, while elemental tissue composition was measured by inductively coupled plasma mass spectrometry. Cecal microbiota profiling was conducted using 16S gene sequencing on the MiSeq platform. Statistical analyses were performed using the Mann-Whitney U-test.
Group I showed an 11.2% increase in body weight gain and a 9.6% reduction in feed conversion ratio compared to controls (p = 0.074; p = 0.063). Group II demonstrated superior weight gain (17.9%) but incurred a 3.6% increase in feed costs. Digestibility of crude fat and protein improved significantly in Group II (p = 0.037). Elemental analysis indicated that lactulose supplementation enhanced the accumulation of magnesium, calcium, manganese, cobalt, zinc, and chromium in muscle tissue. Microbiota analysis revealed that Group I increased abundance and suppressed , while Group II favored the proliferation of , and
Both OMFA formulations enhanced productivity and modulated gut microbiota. The four-component OMFA improved feed efficiency and mineral deposition, while the three-component version elicited greater weight gains. These findings support the incorporation of OMFA as a strategic tool in antibiotic-free poultry production. Further studies are warranted to elucidate the metabolic interactions among additive components and their long-term effects on gut health and performance.
全球对高效家禽生产的需求促使人们寻找抗生素生长促进剂的替代品。本研究旨在评估一种新型的四组分有机矿物质饲料添加剂（OMFA），其包含乳果糖、精氨酸、超细二氧化硅颗粒和琥珀酸，以及一种三组分变体（不含乳果糖）对爱拔益加肉鸡生长性能、养分消化率、元素组织组成和盲肠微生物群的影响。
105只1日龄肉鸡随机分为三组：对照组、I组（四组分OMFA）和II组（三组分OMFA）。在42天的时间内每周记录生长指标。通过平衡实验评估养分消化率，同时通过电感耦合等离子体质谱法测量元素组织组成。在MiSeq平台上使用16S基因测序进行盲肠微生物群分析。使用曼-惠特尼U检验进行统计分析。
与对照组相比，I组体重增加了11.2%，饲料转化率降低了9.6%（p = 0.074；p = 0.063）。II组体重增加更显著（17.9%），但饲料成本增加了3.6%。II组粗脂肪和蛋白质的消化率显著提高（p = 0.037）。元素分析表明，添加乳果糖可增强肌肉组织中镁、钙、锰、钴、锌和铬的积累。微生物群分析显示，I组增加了[未提及具体细菌名称1]的丰度并抑制了[未提及具体细菌名称2]，而II组则有利于[未提及具体细菌名称3]的增殖。
两种OMFA配方均提高了生产性能并调节了肠道微生物群。四组分OMFA提高了饲料效率和矿物质沉积，而三组分配方则带来了更大的体重增加。这些发现支持将OMFA作为无抗生素家禽生产中的一种战略工具。有必要进一步研究以阐明添加剂成分之间的代谢相互作用及其对肠道健康和性能的长期影响。
