Li Wenzheng, Zeng Min, Wan Yuhao, Shi Jing, Liang Yaodan, Chai Ke, Sun Ning, He Wei, Wang Hua, Yang Jiefu
Department of Cardiology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, 100730 Beijing, China.
Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, 100730 Beijing, China.
Rev Cardiovasc Med. 2025 Aug 21;26(8):37636. doi: 10.31083/RCM37636. eCollection 2025 Aug.
To examine the predictive value of the Timed Up and Go test (TUGT) for five-year mortality among older patients with cardiovascular disease (CVD).
This prospective cohort study was conducted at the Beijing Hospital in China from September 2018 to April 2019, with a follow-up period of 5 years. Patients underwent the TUGT at baseline and were categorized into two groups based on the subsequent results: Group 1 (TUGT >15 s) and Group 2 (TUGT ≤15 s). The primary outcome of the study was all-cause mortality over five years.
The study included 491 older patients from the cardiology ward (average age 74.83 ± 6.38 years; 50.92% male). A total of 69 patients (14.05%) died over the five-year follow-up period. Patients in Group 1 were significantly older (78.36 ± 6.39 vs. 73.47 ± 5.83; < 0.001) and exhibited higher prevalence rates of heart failure (HF) (21.17% vs. 11.86%; = 0.009) and stroke or transient ischemic attack (TIA) (24.09% vs. 12.15%; = 0.001) compared to those in Group 2. After adjusting for covariates, multivariate Cox regression analysis revealed that a TUGT >15 s in CVD patients was significantly associated with an elevated hazard ratio for five-year all-cause mortality (hazard ratio (HR): 2.029; 95% confidence interval (CI): 1.198-3.437; = 0.004).
The TUGT is independently associated with 5-year all-cause mortality among older patients with CVD, with a TUGT >15 s indicating a poorer prognosis.
ChiCTR1800017204; date of registration: 07/18/2018. URL: https://www.chictr.org.cn/showproj.html?proj=28931.
探讨计时起立行走测试（TUGT）对老年心血管疾病（CVD）患者五年死亡率的预测价值。
本前瞻性队列研究于2018年9月至2019年4月在中国北京医院进行，随访期为5年。患者在基线时进行TUGT测试，并根据后续结果分为两组：第1组（TUGT>15秒）和第2组（TUGT≤15秒）。该研究的主要结局是五年全因死亡率。
该研究纳入了491名来自心内科病房的老年患者（平均年龄74.83±6.38岁；男性占50.92%）。在五年随访期内，共有69名患者（14.05%）死亡。与第2组患者相比，第1组患者年龄显著更大（78.36±6.39岁对73.47±5.83岁；P<0.001），心力衰竭（HF）患病率更高（21.17%对11.86%；P=0.009），中风或短暂性脑缺血发作（TIA）患病率更高（24.09%对12.15%；P=0.001）。在调整协变量后，多因素Cox回归分析显示，CVD患者TUGT>15秒与五年全因死亡率的风险比升高显著相关（风险比（HR）：2.029；95%置信区间（CI）：1.198 - 3.437；P=0.004）。
TUGT与老年CVD患者的五年全因死亡率独立相关，TUGT>15秒表明预后较差。
ChiCTR1800017204；注册日期：2018年7月18日。网址：https://www.chictr.org.cn/showproj.html?proj=28931 。
