International Healthcare Center, Samsung Medical Center, Korea.
Department of Digital Health, Sungkyunkwan University, Korea.
Eur J Prev Cardiol. 2021 Apr 10;28(2):213–219. doi: 10.1177/2047487319882118. Epub 2019 Oct 20.
This study aimed to evaluate the relationship between Timed Up and Go test performance and the incidence of older adult heart diseases and mortality.
This was a retrospective cohort study of 1,084,875 older adults who participated in a national health screening program between 2009-2014 (all aged 66 years old). Participants free of myocardial infarction, congestive heart failure, and atrial fibrillation at baseline were included and were divided into Group 1 (<10 s), Group 2 (10-20 s) and Group 3 (≥20 s) using the Timed Up and Go test scores. The endpoints were incident myocardial infarction, congestive heart failure, atrial fibrillation, and all-cause mortality.
During mean follow-up of 3.6 years (maximum 8.0 years), 8885 myocardial infarctions, 10,617 congestive heart failures, 15,322 atrial fibrillations, and 22,189 deaths occurred. Compared with participants in Group 1, Group 2 and Group 3 participants had higher incidences of myocardial infarction (Group 3: adjusted hazard ratio = 1.40, 95% confidence interval = 1.11-1.77), congestive heart failure (Group 3: adjusted hazard ratio = 1.59, 95% confidence interval = 1.31-1.94) and total mortality (Group 3: adjusted hazard ratio=1.93, 95% confidence interval = 1.69-2.20). The additional risks remained after adjusting for multiple conventional risk factors. For atrial fibrillation, a linear trend of increased risk was observed with slower Timed Up and Go test speed, but was statistically marginal (Group 3: adjusted hazard ratio=1.17, 95% confidence interval=0.96-1.44).
Slower Timed Up and Go test speed is associated with increased risk of developing myocardial infarction, congestive heart failure, and mortality in older adults.
本研究旨在评估计时起立行走测试表现与老年人心血管疾病发病率和死亡率之间的关系。
这是一项回顾性队列研究，纳入了 2009-2014 年间参加全国健康筛查计划的 1084875 名 66 岁以上老年人（均无心肌梗死、充血性心力衰竭和心房颤动病史）。根据计时起立行走测试得分，将参与者分为三组：第 1 组（<10 秒）、第 2 组（10-20 秒）和第 3 组（≥20 秒）。终点事件为心肌梗死、充血性心力衰竭、心房颤动和全因死亡率。
在平均 3.6 年（最长 8.0 年）的随访期间，发生了 8885 例心肌梗死、10617 例充血性心力衰竭、15322 例心房颤动和 22189 例死亡。与第 1 组相比，第 2 组和第 3 组参与者的心肌梗死（第 3 组：调整后的危险比=1.40，95%置信区间=1.11-1.77）、充血性心力衰竭（第 3 组：调整后的危险比=1.59，95%置信区间=1.31-1.94）和全因死亡率（第 3 组：调整后的危险比=1.93，95%置信区间=1.69-2.20）发生率更高。在调整了多种常规危险因素后，这种额外的风险仍然存在。对于心房颤动，随着计时起立行走测试速度的减慢，风险呈线性增加趋势，但统计学上处于边缘状态（第 3 组：调整后的危险比=1.17，95%置信区间=0.96-1.44）。
计时起立行走测试速度较慢与老年人心肌梗死、充血性心力衰竭和死亡率的风险增加有关。
