Singh Rishabh, Sudhanshu Vaibhav Kumar, Shafiq Mariam, Sharma Markanday
Consort Psychiatr. 2025 Mar 7;6(1):30-36. doi: 10.17816/CP15563. eCollection 2025.
Fixed drug eruption is a type of adverse drug reaction affecting the skin, marked by recurrent rashes that appear at the same site each time a particular drug is taken. Generalized bullous fixed drug eruption (GBFDE) is a severe form of FDE characterized by vesicles or bullae and involvement of a significant portion of the body surface area. To date, no association between GBFDE and chlordiazepoxide has been reported in the literature.
The authors present the case of a 40-year-old male inpatient in the psychiatry department of a tertiary care hospital in Assam, India. The patient was admitted in an alcohol withdrawal state and was initially prescribed chlordiazepoxide at a dose of 60 mg/day. He developed GBFDE within a day of chlordiazepoxide administration. The drug was discontinued, and he was treated with oral and topical corticosteroids instead, resulting in a significant improvement.
Chlordiazepoxide is a rare but potential trigger of GBFDE. Clinicians should closely monitor patients on chlordiazepoxide for possible signs of GBFDE.
固定性药疹是一种影响皮肤的药物不良反应，其特征为每次服用特定药物时在同一部位反复出现皮疹。泛发性大疱性固定性药疹（GBFDE）是固定性药疹的一种严重形式，表现为水疱或大疱，累及身体表面积的很大一部分。迄今为止，文献中尚未报道GBFDE与氯氮䓬之间存在关联。
作者介绍了印度阿萨姆邦一家三级护理医院精神科一名40岁男性住院患者的病例。该患者因酒精戒断状态入院，最初服用氯氮䓬，剂量为60毫克/天。在服用氯氮䓬一天内，他出现了GBFDE。停用该药物，转而用口服和外用皮质类固醇进行治疗，结果有显著改善。
氯氮䓬是GBFDE一种罕见但潜在的诱发因素。临床医生应密切监测服用氯氮䓬的患者是否有GBFDE的可能迹象。
