Baye Gelagey, Wondmneh Bayu, Ashenef Baye, Jemal Mohammed, Baylie Temesgen, Mengistu Enyew Fenta, Adugna Adane
Department of Biomedical Science, Debre Markos University, Debre Markos, Ethiopia.
Department of Medical Laboratory Science, College of Health Sciences, Debre Markos University, Debre Markos, Ethiopia.
Am Heart J Plus. 2025 Aug 28;58:100601. doi: 10.1016/j.ahjo.2025.100601. eCollection 2025 Oct.
Cigarette smoking is a well-recognized independent risk factor for numerous cardiovascular disorders and contributes to the increasing morbidity and mortality associated with chronic heart diseases (CHD). This study aimed to evaluate how cigarette smoking affects lipid metabolism and inflammatory processes, along with other related mechanisms, in order to better understand the potential cardiovascular risks faced by smokers.
To evaluate and compare the serum lipid profile and high-sensitivity C-reactive protein levels between cigarette smokers and non-smokers.
A hospital-based comparative cross-sectional study was conducted from December 2023 to May 2024 in East Gojjam, Ethiopia. The study included 150 cigarette smokers and 150 non-smokers. Independent -tests and ANOVA were used to compare the mean lipid profiles and high-sensitivity C-reactive protein levels between smokers and non-smokers. A -value of <0.05 was considered statistically significant.
The mean serum levels of total cholesterol, low-density lipoprotein, triglycerides, high-density lipoprotein, and high-sensitivity C-reactive protein in cigarette smokers were 178.46 ± 76.34 mg/dL, 112.36 ± 73.58 mg/dL, 138.80 ± 61.88 mg/dL, 38.33 ± 7.99 mg/dL, and 6.26 ± 5.53 mg/L, respectively. These values were significantly different from those of non-smokers (-value <0.05).
Serum mean levels of total cholesterol, low-density lipoprotein, triglycerides, and high-sensitivity C-reactive protein were significantly higher in cigarette smokers compared to non-smokers. In contrast, the mean serum level of high-density lipoprotein was significantly lower in smokers. These changes-elevated TC, LDL-C, TG, and hsCRP, along with decreased HDL-C-may increase the risk of cardiovascular diseases among cigarette smokers.
吸烟是众多心血管疾病公认的独立危险因素，导致与慢性心脏病（CHD）相关的发病率和死亡率不断上升。本研究旨在评估吸烟如何影响脂质代谢和炎症过程以及其他相关机制，以便更好地了解吸烟者面临的潜在心血管风险。
评估并比较吸烟者和非吸烟者的血脂谱及高敏C反应蛋白水平。
2023年12月至2024年5月在埃塞俄比亚东戈贾姆进行了一项基于医院的比较横断面研究。该研究纳入了150名吸烟者和150名非吸烟者。采用独立样本t检验和方差分析比较吸烟者和非吸烟者的平均血脂谱及高敏C反应蛋白水平。P值<0.05被认为具有统计学意义。
吸烟者的总胆固醇、低密度脂蛋白、甘油三酯、高密度脂蛋白和高敏C反应蛋白的平均血清水平分别为178.46±76.34mg/dL、112.36±73.58mg/dL、138.80±61.88mg/dL、38.33±7.99mg/dL和6.26±5.53mg/L。这些值与非吸烟者的值有显著差异（P值<0.05）。
与非吸烟者相比，吸烟者的总胆固醇、低密度脂蛋白、甘油三酯和高敏C反应蛋白的血清平均水平显著更高。相比之下，吸烟者的高密度脂蛋白平均血清水平显著更低。这些变化——总胆固醇、低密度脂蛋白胆固醇、甘油三酯和高敏C反应蛋白升高，以及高密度脂蛋白胆固醇降低——可能会增加吸烟者患心血管疾病的风险。
