临床前痴呆评定分数与血浆磷酸化tau-217相关。
Preclinical dementia rating scores are associated with plasma phosphorylated tau-217.
作者信息
Huang Qi, Jonaitis Erin M, Studer Rachel L, Wilson Rachael, Reyes Ramiro Eduardo Rea, Zetterberg Henrik, Du Lianlian, Hermann Bruce P, Johnson Sterling C, Langhough Rebecca E
机构信息
Department of Educational Studies Purdue University College of Education West Lafayette Indiana USA.
Wisconsin Alzheimer's Institute University of Wisconsin-Madison School of Medicine and Public Health Madison Wisconsin USA.
出版信息
Alzheimers Dement (Amst). 2025 Sep 7;17(3):e70179. doi: 10.1002/dad2.70179. eCollection 2025 Jul-Sep.
INTRODUCTION
Simple screening tools are critical for assessing Alzheimer's disease (AD)-related pre-dementia changes. This study investigated longitudinal scores from the Quick Dementia Rating System (QDRS), a brief study partner-reported measure, in relation to baseline levels of the AD biomarker plasma pTau217 in individuals unimpaired at baseline.
METHODS
Data from the Wisconsin Registry for Alzheimer's Prevention (N = 639) were used to examine whether baseline plasma pTau217 (ALZpath assay on Quanterix platform) modified QDRS or Preclinical Alzheimer's Cognitive Composite (PACC3) trajectories (mixed-effects models; time = age). pTau217*age interaction effects (e.g., high vs low pTau217 simple age slopes) were compared across outcomes.
RESULTS
Higher baseline pTau217 levels were associated with faster functional (QDRS) and cognitive (PACC3) decline. Effect sizes were similar between PACC3 and QDRS. Exploratory analyses showed increased risk of transitioning to impaired QDRS classifications in those with high-baseline pTau217.
DISCUSSION
This study demonstrates the utility of QDRS for tracking pre-dementia AD-related decline.
引言
简单的筛查工具对于评估与阿尔茨海默病（AD）相关的痴呆前变化至关重要。本研究调查了快速痴呆评定系统（QDRS）的纵向评分，这是一种简短的由研究伙伴报告的测量方法，与基线时未受损个体的AD生物标志物血浆pTau217的基线水平相关。
方法
使用来自威斯康星州阿尔茨海默病预防登记处（N = 639）的数据，检查基线血浆pTau217（Quanterix平台上的ALZpath检测）是否改变了QDRS或临床前阿尔茨海默病认知综合评分（PACC3）轨迹（混合效应模型；时间 = 年龄）。比较了pTau217*年龄交互效应（例如，高pTau217与低pTau217的简单年龄斜率）在不同结果之间的差异。
结果
较高的基线pTau217水平与更快的功能（QDRS）和认知（PACC）下降相关。PACC3和QDRS之间的效应大小相似。探索性分析表明，基线pTau217水平高的个体转变为受损QDRS分类的风险增加。
讨论
本研究证明了QDRS在追踪痴呆前AD相关衰退方面的实用性。
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