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开放手术与机器人辅助肾移植术中及术后结果的比较:一项荟萃分析和系统评价

Comparison of intraoperative and postoperative outcomes between open and robotic-assisted kidney transplantation: a meta-analysis and systematic review.

作者信息

Chen Yushui, Cai Songzhi, Wu Yinyu, Wang Yu, Fan Gen, Li Yang, Tang Tielong

机构信息

Department of Urology/School of Clinical Medicine, North Sichuan Medical College/Affiliated Hospital of North Sichuan Medical College, No. 1, South Maoyuan Road, Shunqing District, Nanchong City, 63700, Sichuan Province, China.

出版信息

J Robot Surg. 2025 Sep 10;19(1):584. doi: 10.1007/s11701-025-02732-4.

DOI:10.1007/s11701-025-02732-4
PMID:40928537
Abstract

Renal transplantation is the best option for end-stage renal disease, and in this study, patients who underwent robotic-assisted renal transplantation (RAKT) and open renal transplantation (OKT) were selected to compare their intraoperative and postoperative clinical outcomes: including Operation Time, Length of Stay, WIT (warm ischaemia time), CIT (cold ischaemia time), Estimated Blood Loss, Post 1 month Creatinine, Incision Length, Rewarming Time, Wound infection. The study was registered in PROSPERO with CRD code: CRD420251061084. We searched in Web of Science, Pubmed, Wiely, Elsevier databases, screened according to inclusion and exclusion criteria and finally included 7 papers. The quality of the included literature was assessed using the Newcastle-Ottawa Scale, and the intraoperative and postoperative clinical outcomes were analysed using StataMP 16, with forest plots drawn, and we analysed heterogeneity; sensitivity analyses were carried out using the one-by-one exclusion method, publication bias analyses were performed using the Egger test, and subgroup analyses were carried out for the operation time. RAKT has less Estimated Blood Loss: SMD (95% CI) was -0.577 (-0.755,0.399), I = 35.0%, p = 0.139, shorter Incision length: SMD (95% CI) was -7.114 (-7.568,-6.660), I = 0.0%, p = 0.447, and longer CIT: SMD (95% CI) was 0.408 (0.263,0.554), I = 0.00%, p = 0.575 compared to OKT, and is recommended for patients about to undergo kidney transplantation. Compared with OKT, RAKT results in less blood loss, shorter incision length, and CIT. RAKT is recommended as the first choice for patients undergoing kidney transplantation.

摘要

肾移植是终末期肾病的最佳选择,在本研究中,选取接受机器人辅助肾移植(RAKT)和开放性肾移植(OKT)的患者,比较其术中和术后的临床结局:包括手术时间、住院时间、热缺血时间(WIT)、冷缺血时间(CIT)、估计失血量、术后1个月肌酐水平、切口长度、复温时间、伤口感染情况。该研究已在国际前瞻性系统评价注册库(PROSPERO)注册,注册号为:CRD420251061084。我们检索了科学网、PubMed、威立、爱思唯尔数据库,根据纳入和排除标准进行筛选,最终纳入7篇文献。采用纽卡斯尔-渥太华量表评估纳入文献的质量,使用StataMP 16分析术中和术后的临床结局,绘制森林图,并分析异质性;采用逐一排除法进行敏感性分析,使用Egger检验进行发表偏倚分析,并对手术时间进行亚组分析。与OKT相比,RAKT的估计失血量更少:标准化均数差(SMD,95%可信区间)为-0.577(-0.755,-0.399),I=35.0%,p=0.139;切口长度更短:SMD(95%可信区间)为-7.114(-7.568,-6.660),I=0.0%,p=0.447;CIT更长:SMD(95%可信区间)为0.408(0.263,0.554),I=0.00%,p=0.575,因此推荐用于即将接受肾移植的患者。与OKT相比,RAKT导致的失血量更少、切口长度更短且CIT更长。RAKT被推荐为肾移植患者的首选。

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本文引用的文献

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A comparative study on outcomes of ABO-incompatible kidney transplants between robot-assisted vs. open surgery-propensity score-matched analysis: a retrospective cohort study.机器人辅助与开放手术治疗 ABO 不相容肾移植结局的对比研究——倾向评分匹配分析:一项回顾性队列研究。
BMC Nephrol. 2024 Nov 14;25(1):410. doi: 10.1186/s12882-024-03842-1.
2
Robot-assisted kidney transplantation: a propensity score-matched cohort analysis of early experience.机器人辅助肾移植:早期经验的倾向评分匹配队列分析
Int J Surg. 2024 Nov 1;110(11):7121-7133. doi: 10.1097/JS9.0000000000002019.
3
Robotic kidney transplant has superior outcomes compared to open kidney transplant: results of a propensity match analysis.
与开放性肾移植相比,机器人辅助肾移植具有更好的疗效:倾向匹配分析结果
Surg Endosc. 2025 Jan;39(1):448-458. doi: 10.1007/s00464-024-11301-z. Epub 2024 Oct 5.
4
Economic Evaluations of Robotic-Assisted Surgery: Methods, Challenges and Opportunities.机器人辅助手术的经济评估:方法、挑战与机遇
Appl Health Econ Health Policy. 2025 Jan;23(1):35-49. doi: 10.1007/s40258-024-00920-1. Epub 2024 Sep 27.
5
Robotic Kidney Transplant Beyond the Learning Curve: 8-Year Single-center Experience and Matched Comparison With Open Kidney Transplant.机器人辅助肾移植超越学习曲线:8 年单中心经验及与开放肾移植的匹配对照研究。
Urology. 2024 Jan;183:100-105. doi: 10.1016/j.urology.2023.10.031. Epub 2023 Nov 10.
6
Robot-assisted versus conventional open kidney transplantation: a propensity matched comparison with median follow-up of 5 years.机器人辅助与传统开放性肾移植:倾向匹配比较及5年中位随访
Am J Clin Exp Urol. 2023 Apr 15;11(2):168-176. eCollection 2023.
7
Robotic-assisted Versus Open Technique for Living Donor Kidney Transplantation: A Comparison Using Propensity Score Matching for Intention to Treat.机器人辅助与开放技术用于活体供肾移植:基于倾向评分匹配的意向性治疗比较。
Transplant Direct. 2022 Apr 12;8(5):e1320. doi: 10.1097/TXD.0000000000001320. eCollection 2022 May.
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Robot-assisted kidney transplantation as a minimally invasive approach for kidney transplant recipients: A systematic review and meta-analyses.机器人辅助肾移植作为肾移植受者的微创方法:系统评价和荟萃分析。
Int J Surg. 2022 Mar;99:106264. doi: 10.1016/j.ijsu.2022.106264. Epub 2022 Feb 17.
9
Robot-assisted kidney transplantation: State of art.机器人辅助肾移植:现状。
Arch Esp Urol. 2021 Dec;74(10):970-978.
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Int J Clin Pract. 2021 Aug;75(8):e14288. doi: 10.1111/ijcp.14288. Epub 2021 May 13.