Dubey S S, Sinha K K, Gupta J P
Indian J Physiol Pharmacol. 1985 Apr-Jun;29(2):111-4.
Studies were conducted to evaluate the blood levels of ascorbic acid, dehydroascorbic acid, glutathione, and histamine in patients with gastric carcinoma, tuberculous enteritis and non-specific ulcerative colitis. Leucocyte ascorbic acid, urinary excretion of total ascorbic acid and ascorbic acid saturation test were also carried out in order to assess the ascorbic acid status of these patients. It was observed that the plasma and leucocyte content of ascorbic acid was significantly lower with markedly decreased urinary excretion in these patients. Further urinary excretion of ascorbic acid after a test dose was also found to be subnormal. Decreased levels of glutathione and significantly higher levels of histamine reflect an overall reducing status of the body is markedly deranged.
开展了多项研究，以评估胃癌、结核性肠炎和非特异性溃疡性结肠炎患者体内抗坏血酸、脱氢抗坏血酸、谷胱甘肽和组胺的血液水平。还进行了白细胞抗坏血酸、总抗坏血酸的尿排泄量及抗坏血酸饱和试验，以评估这些患者的抗坏血酸状态。据观察，这些患者血浆和白细胞中的抗坏血酸含量显著降低，尿排泄量明显减少。此外，给予试验剂量后抗坏血酸的尿排泄量也低于正常水平。谷胱甘肽水平降低以及组胺水平显著升高表明机体整体还原状态明显紊乱。
