Eliasson Isabelle, Wyss Katja, Tafesse Bogale Rebecca, Forsblom Sofia, Lindquist Emil, Rönnberg Caroline, Hansson Magnus, Beshara Soheir, Nordling Irene, Hertting Olof, Wångdahl Andreas, Färnert Anna
Division of Infectious Diseases, Department of Medicine Solna and Centre for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden.
Department of Infectious Diseases, Karolinska University Hospital, Stockholm, Sweden.
Open Forum Infect Dis. 2025 Sep 2;12(9):ofaf525. doi: 10.1093/ofid/ofaf525. eCollection 2025 Sep.
Migrants from malaria-endemic areas may have asymptomatic parasitemia that persists after relocating to nonendemic countries. Recommendations on malaria screening and treatment of asymptomatic infections in migrants are lacking. The aim of this study was to explore the clinical features of subclinical blood-stage infections in migrants, to inform screening and management strategies.
A retrospective observational study was performed to evaluate clinical data from medical records of asymptomatic sub-Saharan African migrants identified with parasitic infection within a screening study in Stockholm, Sweden. Clinical data from hospital outpatient visits were compared between malaria polymerase chain reaction (PCR)-positive and PCR-negative individuals, the latter assessed for schistosomiasis and/or strongyloidiasis.
Clinical features and chemistry tests from 65 PCR-positive individuals were compared with data from 54 PCR-negative individuals. Study participants with infection had a higher proportion of anemia (21.1% vs 6.1%, = .048), elevated erythrocyte sedimentation rate (ESR) (58.1% vs 25.0%, = .008), raised plasma/serum immunoglobulin M (30.5% vs 10.5%, = .030), and splenomegaly (25.4% vs 2.5%, = .002). After antimalarial treatment, splenomegaly and laboratory parameters improved in -infected individuals.
Migrants with subclinical infection have a high proportion of splenomegaly and abnormal laboratory findings, such as anemia and elevated ESR. Screening and treatment of subclinical malaria infections could prevent adverse outcomes and should be considered both in endemic and nonendemic settings.
来自疟疾流行地区的移民可能有无症状寄生虫血症，在迁移到非流行国家后仍会持续存在。目前缺乏关于移民无症状感染的疟疾筛查和治疗的建议。本研究的目的是探索移民中亚临床血液阶段感染的临床特征，为筛查和管理策略提供依据。
进行了一项回顾性观察研究，以评估在瑞典斯德哥尔摩的一项筛查研究中确定为寄生虫感染的无症状撒哈拉以南非洲移民的医疗记录中的临床数据。比较了疟疾聚合酶链反应（PCR）阳性和PCR阴性个体的医院门诊临床数据，后者评估是否感染血吸虫病和/或类圆线虫病。
将65名PCR阳性个体的临床特征和化学检测结果与54名PCR阴性个体的数据进行了比较。感染的研究参与者贫血比例更高（21.1%对6.1%，P = 0.048），红细胞沉降率（ESR）升高（58.1%对25.0%，P = 0.008），血浆/血清免疫球蛋白M升高（30.5%对10.5%，P = 0.030），脾肿大比例更高（25.4%对2.5%，P = 0.002）。抗疟治疗后，感染个体的脾肿大和实验室参数有所改善。
亚临床感染的移民脾肿大比例高，并有贫血和ESR升高等异常实验室检查结果。筛查和治疗亚临床疟疾感染可以预防不良后果，在流行和非流行地区均应予以考虑。
