Obeidat Adham E, Mahfouz Ratib T, Shah Parthav K, Kozai Landon A, Darweesh Mohammad R, Mansour Mahmoud M, Yassine Ahmad A, Kuwada Scott K, Chang Christopher H
Department of Internal Medicine, Presbyterian Healthcare System, Albuquerque, NM 87106.
Department of Nephrology, Henry Ford Hospital, Detroit, MI 48202.
Porto Biomed J. 2025 Sep 10;10(5):e302. doi: 10.1097/j.pbj.0000000000000302. eCollection 2025 Sep-Oct.
Patients with aortic stenosis undergoing noncardiac surgery pose a dilemma to physicians as they are at an increased risk for complications. This study aims to investigate the effect of aortic stenosis on mortality and other complications in patients with pancreatic cancer undergoing pancreaticoduodenectomy.
We investigated patients with pancreatic cancer undergoing pancreaticoduodenectomy between 2016 and 2019 using the National Inpatient Sample database. The study population was divided based on the presence or absence of aortic stenosis. Multivariate logistic regression analyses were performed to determine factors associated with in-hospital mortality and other complications.
Of the 16,150 patients with pancreatic cancer who underwent pancreaticoduodenectomy, 165 patients were diagnosed with aortic stenosis. The mean age of patients with aortic stenosis was significantly higher. Patients with aortic stenosis had a significantly higher in-hospital mortality, occurrence of cardiac arrest, and ICU admission compared with patients without aortic stenosis. There was no difference in mechanical ventilation, hospital charges, and length of stay between the two groups.
Aortic stenosis was found to be associated with higher in-hospital mortality and worse outcomes in patients with pancreatic cancer undergoing pancreaticoduodenectomy. Preoperative risk stratification and a multidisciplinary approach to perioperative management, among other measures, should be considered to improve outcomes.
接受非心脏手术的主动脉瓣狭窄患者给医生带来了两难困境，因为他们发生并发症的风险增加。本研究旨在调查主动脉瓣狭窄对接受胰十二指肠切除术的胰腺癌患者死亡率和其他并发症的影响。
我们使用国家住院样本数据库调查了2016年至2019年间接受胰十二指肠切除术的胰腺癌患者。根据是否存在主动脉瓣狭窄对研究人群进行划分。进行多因素逻辑回归分析以确定与住院死亡率和其他并发症相关的因素。
在16150例接受胰十二指肠切除术的胰腺癌患者中，165例被诊断为主动脉瓣狭窄。主动脉瓣狭窄患者的平均年龄显著更高。与无主动脉瓣狭窄的患者相比，主动脉瓣狭窄患者的住院死亡率、心脏骤停发生率和入住重症监护病房的比例显著更高。两组在机械通气、住院费用和住院时间方面没有差异。
发现主动脉瓣狭窄与接受胰十二指肠切除术的胰腺癌患者较高的住院死亡率和较差的预后相关。应考虑采取术前风险分层和多学科围手术期管理方法等措施以改善预后。
