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The glyoxalase system: A new target for inflammatory diseases.

作者信息

Yang Yingyi, Kang Rui, Zhou Huiting, Tang Daolin

机构信息

Institute of Pediatric Research, Children's Hospital of Soochow University, Suzhou, Jiangsu, China.

Department of Surgery, UT Southwestern Medical Center, Dallas, TX, USA.

出版信息

J Intensive Med. 2025 Apr 11;5(3):216-218. doi: 10.1016/j.jointm.2025.03.002. eCollection 2025 Jul.

DOI:10.1016/j.jointm.2025.03.002
PMID:40933748
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12417358/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4cd8/12417358/ee71c09cd8e7/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4cd8/12417358/ee71c09cd8e7/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4cd8/12417358/ee71c09cd8e7/gr1.jpg

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本文引用的文献

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Lactylation and human disease.乳酰化与人类疾病。
Expert Rev Mol Med. 2025 Feb 3;27:e10. doi: 10.1017/erm.2025.3.
2
Itaconate drives pro-inflammatory responses through proteasomal degradation of GLO1.衣康酸通过蛋白酶体降解GLO1来驱动促炎反应。
Biochem Biophys Res Commun. 2025 Feb 2;747:151292. doi: 10.1016/j.bbrc.2025.151292. Epub 2025 Jan 6.
3
Mechanisms of metabolism-coupled protein modifications.代谢偶联蛋白修饰的机制。
Nat Chem Biol. 2025 Jan 7. doi: 10.1038/s41589-024-01805-z.
4
Nonenzymatic lysine D-lactylation induced by glyoxalase II substrate SLG dampens inflammatory immune responses.乙二醛酶II底物SLG诱导的非酶促赖氨酸D-乳酰化可减轻炎症免疫反应。
Cell Res. 2025 Feb;35(2):97-116. doi: 10.1038/s41422-024-01060-w. Epub 2025 Jan 6.
5
Mitochondrial ACOD1/IRG1 in infection and sterile inflammation.感染和无菌性炎症中的线粒体ACOD1/IRG1
J Intensive Med. 2022 Feb 12;2(2):78-88. doi: 10.1016/j.jointm.2022.01.001. eCollection 2022 Apr.
6
Histone Lactylation Boosts Reparative Gene Activation Post-Myocardial Infarction.组蛋白乳酰化促进心肌梗死后修复性基因的激活。
Circ Res. 2022 Nov 11;131(11):893-908. doi: 10.1161/CIRCRESAHA.122.320488. Epub 2022 Oct 21.
7
Aconitate decarboxylase 1 is a mediator of polymicrobial sepsis.乌头酸酶 1 是多微生物脓毒症的介质。
Sci Transl Med. 2022 Aug 24;14(659):eabo2028. doi: 10.1126/scitranslmed.abo2028.
8
Lactate promotes macrophage HMGB1 lactylation, acetylation, and exosomal release in polymicrobial sepsis.乳酸促进多微生物脓毒症中巨噬细胞 HMGB1 的乳酰化、乙酰化和胞外体释放。
Cell Death Differ. 2022 Jan;29(1):133-146. doi: 10.1038/s41418-021-00841-9. Epub 2021 Aug 6.
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Glyoxalase system: A systematic review of its biological activity, related-diseases, screening methods and small molecule regulators.糖氧还蛋白系统：系统综述其生物学活性、相关疾病、筛选方法和小分子调节剂。
Biomed Pharmacother. 2020 Nov;131:110663. doi: 10.1016/j.biopha.2020.110663. Epub 2020 Aug 25.
10
Immunometabolism: From basic mechanisms to translation.免疫代谢：从基础机制到转化。
Immunol Rev. 2020 May;295(1):5-14. doi: 10.1111/imr.12858.