利用四价DNA-捕获抗生物素蛋白构建块构建多功能超分子结构。
Engineering versatile supramolecular structures with tetravalent DNA-traptavidin building blocks.
作者信息
Lee Dayoung Gloria, Kim Young-Youb, Yang Hoonil, Song Yoon-Kyu
机构信息
Department of Applied Bioengineering, Graduate School of Convergence Science and Technology, Seoul National University Seoul 08826 Republic of Korea
Department of Chemical Engineering, Columbia University New York New York 10027 USA.
出版信息
Nanoscale Adv. 2025 Sep 2. doi: 10.1039/d5na00575b.
Proteins offer great promise for nanoscale biomaterials, but precise assembly is challenging. This study presents DNA-protein hybrid building blocks (DTHBs) using traptavidin and biotinylated DNA for controlled assembly to linear chains, spherical clusters, and ordered lattices, enabling sophisticated, programmable architectures with potential biomedical applications, including drug delivery and biosensors.
蛋白质为纳米级生物材料带来了巨大的前景，但精确组装具有挑战性。本研究提出了使用抗生物素蛋白和生物素化DNA的DNA-蛋白质杂交构建块（DTHB），用于将其可控组装成线性链、球形簇和有序晶格，从而实现具有潜在生物医学应用（包括药物递送和生物传感器）的复杂、可编程结构。
Zotero 插件