慢性低灌注伴脑白质高信号患者中MATK的表达及相关性
The expression and association of MATK in chronic hypoperfusion patients with white matter hyperintensity.
作者信息
Zhao Ming, Zhang Jiayue, Yang Qianqian, Chen Lei, Shen Hongjian, Pu Yingyan, Wei Wei, Han Yi, Zhang Ping
机构信息
Department of Neurology, Naval Medical Center of PLA, Naval Medical University, Shanghai, China.
Department of Neurology, Shenzhen Samii International Medical Center (The Fourth People's Hospital of Shenzhen), Shenzhen, China.
出版信息
Front Aging Neurosci. 2025 Aug 26;17:1570482. doi: 10.3389/fnagi.2025.1570482. eCollection 2025.
BACKGROUND
Chronic cerebral hypoperfusion (CCH) is a key contributor to vascular cognitive impairment (VCI). Patients with CCH frequently exhibit white matter hyperintensities (WMH) on MRI. This study investigated the expression and clinical relevance of megakaryocyte-associated tyrosine kinase (MATK) in CCH patients with WMH.
METHODS
We recruited 42 anterior circulation stenosis patients with CCH and WMH (CCH-WMH group) and 45 age-matched healthy controls. MATK mRNA expression in peripheral blood mononuclear cells (PBMCs) was quantified using qPCR. WMH severity was graded using the Fazekas scale. Correlations between MATK expression and imaging/clinical parameters were analyzed using Pearson's correlation and logistic regression. Diagnostic performance was assessed via ROC analysis.
RESULTS
Megakaryocyte-associated tyrosine kinase expression was significantly downregulated in the CCH-WMH group versus controls (1.20 ± 0.99 vs. 1.84 ± 0.87; < 0.01). MATK levels showed a strong negative correlation with Fazekas scores (R = 0.3405, < 0.001). Multivariate regression identified MATK as independently associated with WMH (aOR = 0.492; 95% CI: 0.262-0.923; = 0.027). ROC analysis demonstrated moderate diagnostic accuracy for WMH (AUC = 0.743; 95% CI: 0.637-0.849).
CONCLUSION
Reduced peripheral MATK expression correlates with WMH severity in CCH patients and may serve as a potential diagnostic biomarker.
背景
慢性脑灌注不足（CCH）是血管性认知障碍（VCI）的关键促成因素。CCH患者在MRI上常表现为白质高信号（WMH）。本研究调查了巨核细胞相关酪氨酸激酶（MATK）在伴有WMH的CCH患者中的表达及其临床相关性。
方法
我们招募了42例患有CCH和WMH的前循环狭窄患者（CCH-WMH组）以及45例年龄匹配的健康对照者。使用qPCR定量外周血单个核细胞（PBMC）中MATK mRNA的表达。WMH严重程度采用Fazekas量表进行分级。使用Pearson相关性分析和逻辑回归分析MATK表达与影像学/临床参数之间的相关性。通过ROC分析评估诊断性能。
结果
与对照组相比，CCH-WMH组中巨核细胞相关酪氨酸激酶的表达显著下调（1.20±0.99对1.84±0.87；<0.01）。MATK水平与Fazekas评分呈强烈负相关（R = 0.3405，<0.001）。多变量回归分析确定MATK与WMH独立相关（调整后比值比[aOR]=0.492；95%置信区间[CI]：0.262 - 0.923；P = 0.027）。ROC分析显示对WMH具有中等诊断准确性（曲线下面积[AUC]=0.743；95%CI：0.637 - 0.849）。
结论
CCH患者外周MATK表达降低与WMH严重程度相关，可能作为一种潜在的诊断生物标志物。
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