Peterson Urbee Disha, Beenken Madison, Moua Teng
Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN.
Department of Biostatistics, Mayo Clinic, Rochester, MN.
Mayo Clin Proc Innov Qual Outcomes. 2025 Aug 29;9(5):100660. doi: 10.1016/j.mayocpiqo.2025.100660. eCollection 2025 Oct.
To assess whether self-reported acute mood or affect is associated with other patient-reported outcome measures, lung function, and all-cause mortality, in patients with fibrotic interstitial lung disease (f-ILD).
The Positive and Negative Affect Schedule (PANAS) is a 20-item questionnaire reflecting recent mood or affect over the past week, reported as Positive, Negative, or Ratio (Positive:Negative) subscores. Baseline and serial PANAS scores were assessed for their correlation with the Chronic Respiratory Questionnaire, Self-Management Assessment Scale 30, and lung function over a 3-year study period, and association with incident anxiety, depression, and all-cause mortality.
In total, 199 patients with f-ILD were enrolled. Baseline PANAS scores correlated moderately with Chronic Respiratory Questionnaire and Self-Management Assessment Scale 30 scores. Higher PANAS Positive and Ratio scores were associated with higher percent predicted forced vital capacity. Mean PANAS scores were higher or lower when stratified by clinically suspected anxiety and/or depression and predictive of all-cause mortality on adjusted analysis, respectively. Incident anxiety and/or depression was not associated with worse survival outcome.
Self-reported acute mood or affect may be associated with RR-QoL, lung function, and adjusted all-cause mortality in patients with f-ILD.
评估在纤维化间质性肺病（f-ILD）患者中，自我报告的急性情绪或情感是否与其他患者报告的结局指标、肺功能及全因死亡率相关。
正负性情绪量表（PANAS）是一份包含20个条目的问卷，反映过去一周内的近期情绪或情感，以正性、负性或比例（正性：负性）子分数形式报告。在为期3年的研究期间，评估基线及连续的PANAS评分与慢性呼吸问卷、自我管理评估量表30及肺功能的相关性，以及与新发焦虑、抑郁和全因死亡率的关联。
共纳入199例f-ILD患者。基线PANAS评分与慢性呼吸问卷及自我管理评估量表30评分中度相关。较高的PANAS正性及比例评分与预测的用力肺活量百分比升高相关。根据临床疑似焦虑和/或抑郁分层时，平均PANAS评分分别较高或较低，且在调整分析中可预测全因死亡率。新发焦虑和/或抑郁与较差的生存结局无关。
自我报告的急性情绪或情感可能与f-ILD患者的RR-QoL、肺功能及调整后的全因死亡率相关。
