CD38连接心脏和大脑。
CD38 connects the heart and brain.
作者信息
Tao Yijing, Duan Jiahao, Huang Kai, Wang Ruting, Feng Qinwen, Yang Chun, Zhang Xinying, Yang Ling
机构信息
Department of Cardiology, The Third Affiliated Hospital of Soochow University, Changzhou, 213003, China.
Department of Cardiology, Changshu Hospital Affiliated to Soochow University, Changshu No.1 People's Hospital, Changshu, China.
出版信息
Transl Psychiatry. 2025 Sep 11;15(1):342. doi: 10.1038/s41398-025-03597-9.
Cluster of differentiation 38 (CD38) is a widely expressed transmembrane glycoprotein in various human tissues and cells with vital biological roles in the heart and brain, possessing both NADase and cyclase activities. It is involved in regulating heart and brain functions through various pathways, including calcium (Ca) signaling nicotinamide adenine dinucleotide (NAD) content, oxidative stress, inflammation and immune response. Its combined role in heart-brain coexisting diseases suggests that inhibiting CD38 has a protective effect on cardiovascular diseases (CVD) and neurological disorders. This review aims to discuss the expression patterns, regulatory mechanisms, and CD38 signaling pathways in the heart and brain. In conclusion, CD38 is implicated in the shared pathogenesis of heart-brain diseases, providing novel insights for future research.
分化簇38（CD38）是一种在各种人体组织和细胞中广泛表达的跨膜糖蛋白，在心脏和大脑中具有重要的生物学作用，兼具NAD酶和环化酶活性。它通过多种途径参与调节心脏和大脑功能，包括钙（Ca）信号、烟酰胺腺嘌呤二核苷酸（NAD）含量、氧化应激、炎症和免疫反应。其在心脑共存疾病中的综合作用表明，抑制CD38对心血管疾病（CVD）和神经疾病具有保护作用。本综述旨在探讨CD38在心脏和大脑中的表达模式、调控机制及信号通路。总之，CD38与心脑疾病的共同发病机制有关，为未来研究提供了新的见解。
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