Liu Anyi, Yin Xueqian, Wen Jing, Hou Chao, Zhou Ruoyu, Liu Xinran, Yin Ning, Jian Yuanzhi, Liu Shan, Zhang Xiaoxuan, Wang Junbo
Department of Nutrition and Food Hygiene, School of Public Health, Peking University, Beijing, China.
Key Laboratory of Food Safety Risk Assessment of Ministry of Health, China National Center for Food Safety Risk Assessment, Beijing, China.
GM Crops Food. 2025 Dec;16(1):591-606. doi: 10.1080/21645698.2025.2550820. Epub 2025 Sep 12.
With the rapid adoption of glyphosate-resistant (GR) crops by farmers, the food safety has garnered significant attention. This study aims to evaluate the relative safety of glyphosate-resistant maize (CC-2). Rats were divided into three groups: one group receiving AIN-93 G feed (AIN), one receiving non-modified receptor maize feed (NM), and the other receiving CC-2 maize feed (GM). The intervention spanned from gestation d 0 of the parental rats to 90 d post-weaning of the offspring. The results indicated no significant differences in pregnancy outcomes, body weight, growth monitoring, behavioral tests, or organ indexes between the GM group and the two control groups (AIN and NM). Although there were significant differences in some hematological parameters, serum chemistry, and organ weights, histopathological analysis revealed no abnormalities. No exogenous gene fragments were detected in major organs. In conclusion, CC-2 maize is relative safe for growth and development in rats.
随着农民对耐草甘膦（GR）作物的迅速采用，食品安全问题备受关注。本研究旨在评估耐草甘膦玉米（CC - 2）的相对安全性。将大鼠分为三组：一组接受AIN - 93G饲料（AIN组），一组接受非转基因受体玉米饲料（NM组），另一组接受CC - 2玉米饲料（GM组）。干预从亲代大鼠妊娠第0天开始，持续到子代断奶后90天。结果表明，GM组与两个对照组（AIN组和NM组）在妊娠结局、体重、生长监测、行为测试或器官指数方面无显著差异。虽然在一些血液学参数、血清生化指标和器官重量方面存在显著差异，但组织病理学分析未发现异常。在主要器官中未检测到外源基因片段。总之，CC - 2玉米对大鼠的生长发育相对安全。
