Wan Xinyao, Bi Fangfang, Xin Bing, Qiao Chong
Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China.
Front Oncol. 2025 Aug 27;15:1612716. doi: 10.3389/fonc.2025.1612716. eCollection 2025.
Uterine carcinosarcoma is a rare, highly aggressive malignancy characterized by both carcinomatous and sarcomatous components. Brenner tumors of the ovary are uncommon epithelial neoplasms, usually benign but occasionally coexisting with other pathologies. The co-occurrence of these two entities is extremely rare and poses diagnostic and therapeutic challenges.
We report a case of a 58-year-old female presenting with scant yellowish vaginal discharge. Imaging studies revealed an intrauterine mass. Histopathological analysis of curettage specimens confirmed endometrial malignancy. The patient underwent radical surgical resection followed by histopathological and immunohistochemical analysis.
Histopathology confirmed uterine carcinosarcoma comprising high-grade endometrial adenocarcinoma and pleomorphic sarcoma with chondrosarcoma differentiation. Bilateral ovarian Brenner tumors were also identified. Given the aggressive nature of carcinosarcoma, the patient was referred for adjuvant therapy.
This case highlights the importance of prompt pathological evaluation in atypical gynecologic presentations. Early diagnosis through histopathology and immunohistochemistry is crucial for managing rare and aggressive tumors such as uterine carcinosarcoma, particularly when coexisting with other uncommon neoplasms like Brenner tumors. Multidisciplinary care and individualized treatment plans are essential for optimizing outcomes.
子宫癌肉瘤是一种罕见的、侵袭性很强的恶性肿瘤，其特征是同时具有癌性和肉瘤性成分。卵巢勃勒纳瘤是不常见的上皮性肿瘤，通常为良性，但偶尔会与其他病理情况共存。这两种实体同时出现极为罕见，给诊断和治疗带来了挑战。
我们报告一例58岁女性，表现为少量淡黄色阴道分泌物。影像学检查发现子宫内有肿物。刮宫标本的组织病理学分析证实为子宫内膜恶性肿瘤。患者接受了根治性手术切除，随后进行了组织病理学和免疫组织化学分析。
组织病理学证实为子宫癌肉瘤，由高级别子宫内膜腺癌和具有软骨肉瘤分化的多形性肉瘤组成。还发现双侧卵巢勃勒纳瘤。鉴于癌肉瘤的侵袭性，该患者被转诊接受辅助治疗。
本病例强调了在非典型妇科表现中及时进行病理评估的重要性。通过组织病理学和免疫组织化学进行早期诊断对于管理像子宫癌肉瘤这样罕见且侵袭性强的肿瘤至关重要，尤其是当它与像勃勒纳瘤这样的其他罕见肿瘤共存时。多学科护理和个体化治疗方案对于优化治疗结果至关重要。
