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多部位骨巨细胞瘤功能恢复的优化

Optimizing Functional Recovery in Multi-Site Giant Cell Tumors.

作者信息

Dubey Vinod, Prajapati Mohit, Tolani Mohit, Sharma Shivam

机构信息

Department of Orthopedic, Wockhardt Hospital, Mumbai, Maharashtra, India.

Department of Orthopedic, Shree Krishna Hospital and Medical Research Centre, Pramukhswami Medical College, Bhaikaka University, Anand, Gujarat, India.

出版信息

J Orthop Case Rep. 2025 Sep;15(9):316-321. doi: 10.13107/jocr.2025.v15.i09.6112.

Abstract

INTRODUCTION

Giant cell tumor (GCT) in Orthopedics is a clinically challenging problem pertaining aggressive expansion and recurrence. While GCT's typically occur at epiphyseal ends of long bones, unusual locations, such as tendon sheath, distal ulna, and proximal tibia have been reported, which impose different challenges for management.

CASE SERIES

In this case series, we present surgical methodology tailored for individual characteristics of GCTs, with emphasis on functional recovery. We demonstrate four cases involving different sites GCT - tendon sheath in hand, distal ulna, distal radius, and proximal tibia. Each case was managed using a site-specific surgical approach, ranging from en bloc resection with ulna transposition and arthrodesis to Illizarov assisted bone transport. Emphasis is laid on strategic surgical technique coupled with functional preservation and prevention of recurrence. All patients were successfully treated without recurrences at follow-up ranging 6 months to 2 years. Functional outcomes varied depending on the location and extent of surgical dissection, but improved overall, as evident by patients' return to routine daily activities with significant relief from pain. This case series underscores importance of a tailored, site-specific approach for managing GCT.

CONCLUSION

Strategic surgical intervention employed with limb-sparing technique using reconstructive surgery, highlights the potential for restoration of optimal function while minimizing the risk of recurrence. However, the diversity of GCT presentation necessitates vigilant surveillance and an individualized patient management plan.

摘要

引言

骨科中的骨巨细胞瘤(GCT)是一个临床上具有挑战性的问题,涉及侵袭性扩展和复发。虽然骨巨细胞瘤通常发生在长骨的骨骺端,但也有报道称其发生在不寻常的部位,如腱鞘、尺骨远端和胫骨近端,这给治疗带来了不同的挑战。

病例系列

在本病例系列中,我们展示了根据骨巨细胞瘤的个体特征量身定制的手术方法,重点是功能恢复。我们展示了4例涉及不同部位骨巨细胞瘤的病例——手部腱鞘、尺骨远端、桡骨远端和胫骨近端。每个病例都采用了特定部位的手术方法,从尺骨转位和关节融合的整块切除到伊利扎罗夫辅助骨搬运。重点是战略性的手术技术,同时保留功能并预防复发。所有患者均成功治疗,随访6个月至2年无复发。功能结果因手术解剖的部位和范围而异,但总体有所改善,患者恢复日常活动且疼痛明显缓解即可证明。本病例系列强调了针对骨巨细胞瘤采用量身定制的、特定部位方法的重要性。

结论

采用保肢技术和重建手术进行的战略性手术干预,突出了在将复发风险降至最低的同时恢复最佳功能的潜力。然而,骨巨细胞瘤表现的多样性需要进行密切监测和个体化的患者管理计划。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/06ed/12422679/5c8ffb8daf5d/JOCR-15-316-g001.jpg

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