Wasilewska Barbara, Petruczynik Anna
Department of Inorganic Chemistry, Medical University of Lublin, Chodźki 4a, Lublin, 20-093 Poland.
J Diabetes Metab Disord. 2025 Sep 8;24(2):197. doi: 10.1007/s40200-025-01711-8. eCollection 2025 Dec.
This review assessed the selected information on semaglutide's activity, its potential for the treatment of various diseases, and its pharmacokinetics. It is intended as a guide for future research. Chromatographic procedures used for the determination of semaglutide in various biological samples were also reviewed.
A comprehensive review of the literature was conducted by searching scientific databases including PubMed, Scopus, Web of Science, and Google Scholar. The search was performed using keywords such as diabetic, type of diabetics, impact of diabetic glucagon-like peptide, DPP-4 inhibitors, GLP-1 agonists, semaglutide and weight loss, semaglutide and obesity, semaglutide and diabetic retinopathy, semalutide and mood, semaglutide and mood disorder, semaglutide and fertility, semaglutide and thyroid, semaglutide and inflammation, semaglutide and cardiovascular system, semaglutide and imapct on heart, semaglutide and neuroprotection, semaglutide and pancreatitis, safety of semaglutide, semaglutide and side effects, semaglutide and contraindication, and semaglutide analysis by liquid chromatography.
Semaglutide is the most potent glucose-lowering glucagon-like peptide (GLP-1) analogue and is widely used in the treatment of type 2 diabetes. Semaglutide increases the secretion of insulin from pancreatic β-cells and supresses glucagon release from pancreatic α-cells. Due to its effects on appetite regulation, it is also used to treat obesity in many countries. However, due to the slimming properties of the drug, semaglutide is often abused by non-diabetics, non-obese individuals, and young people. Recently, numerous investigations have been conducted to better understand the mechanism of action, as well as the advantages and disadvantages of using semaglutide. It is also very important to develop sensitive and accurate methods for detecting this drug in various biological samples collected from patients.
Semaglutide is increasingly used of for the treatment of type 2 diabetes; however, its misuse for weight loss is also increasing. Further research is required to confirm the benefits of using semaglutide and to optimize treatment strategies for diverse patient populations.
本综述评估了司美格鲁肽的活性、其治疗各种疾病的潜力及其药代动力学的相关信息。旨在为未来的研究提供指导。还对用于测定各种生物样品中司美格鲁肽的色谱方法进行了综述。
通过检索包括PubMed、Scopus、Web of Science和谷歌学术在内的科学数据库，对文献进行了全面综述。检索使用的关键词包括糖尿病、糖尿病类型、糖尿病胰高血糖素样肽的影响、二肽基肽酶-4抑制剂、胰高血糖素样肽-1激动剂、司美格鲁肽与体重减轻、司美格鲁肽与肥胖、司美格鲁肽与糖尿病视网膜病变、司美格鲁肽与情绪、司美格鲁肽与情绪障碍、司美格鲁肽与生育能力、司美格鲁肽与甲状腺、司美格鲁肽与炎症、司美格鲁肽与心血管系统、司美格鲁肽与对心脏的影响、司美格鲁肽与神经保护、司美格鲁肽与胰腺炎、司美格鲁肽的安全性、司美格鲁肽与副作用、司美格鲁肽与禁忌症以及液相色谱法分析司美格鲁肽。
司美格鲁肽是最有效的降血糖胰高血糖素样肽（GLP-1）类似物，广泛用于治疗2型糖尿病。司美格鲁肽增加胰腺β细胞胰岛素的分泌，并抑制胰腺α细胞胰高血糖素的释放。由于其对食欲调节的作用，它在许多国家也被用于治疗肥胖症。然而，由于该药物的减肥特性，司美格鲁肽经常被非糖尿病患者、非肥胖个体和年轻人滥用。最近，已经进行了大量研究以更好地了解其作用机制以及使用司美格鲁肽的优缺点。开发灵敏准确的方法来检测从患者采集的各种生物样品中的这种药物也非常重要。
司美格鲁肽越来越多地用于治疗2型糖尿病；然而，其用于减肥的滥用情况也在增加。需要进一步研究以证实使用司美格鲁肽的益处，并为不同患者群体优化治疗策略。
