Li Yuanyuan, Zhang Bin, Zhou Ya, Wang Daoming, Liu Xianchen, Li Lin, Wang Tong, Zhang Yuechu, Jiang Min, Tang Huilan, Amsel Lawrence V, Fan Fang, Hoven Christina W
Key Laboratory of Brain, Cognition and Education Sciences, Ministry of Education, China; School of Psychology, Center for Studies of Psychological Application, and Guangdong Key Laboratory of Mental Health and Cognitive Science, South China Normal University, Guangzhou, People's Republic of China.
Expressive Arts Therapy Department, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, People's Republic of China.
Nat Sci Sleep. 2020 Nov 5;12:895-905. doi: 10.2147/NSS.S271927. eCollection 2020.
The major purpose of this study was to detect the changes in gut microbiota composition and inflammatory cytokines production associated with acute and chronic insomnia. This study also evaluated the relationship between gut microbiota changes and increased inflammatory cytokines in insomnia patients.
Outpatients with acute and chronic insomnia (aged 26-55 years; n=20 and 38, respectively) and age/gender-matched healthy controls (n=38) were recruited from a southern China region. Participants' gut microbiome, plasma cytokines, and self-reported sleep quality and psychopathological symptoms were measured.
The gut microbiomes of insomnia patients compared with healthy controls were characterized by lower microbial richness and diversity, depletion of anaerobes, and short-chain fatty acid (SCFA)-producing bacteria, and an expansion of potential pathobionts. and were signature bacteria for distinguishing acute insomnia patients from healthy controls, while and were signature bacteria for distinguishing chronic insomnia patients from healthy controls. Acute/chronic insomnia-related signature bacteria also showed correlations with these patients' self-reported sleep quality and plasma IL-1β.
These findings suggest that insomnia symptomology, gut microbiota, and inflammation may be interrelated in complex ways. Gut microbiota may serve as an important indicator for auxiliary diagnosis of insomnia and provide possible new therapeutic targets in the field of sleep disorders.
本研究的主要目的是检测与急性和慢性失眠相关的肠道微生物群组成变化和炎性细胞因子产生情况。本研究还评估了失眠患者肠道微生物群变化与炎性细胞因子增加之间的关系。
从中国南方地区招募急性和慢性失眠门诊患者（年龄26 - 55岁；分别为20例和38例）以及年龄/性别匹配的健康对照者（38例）。测量参与者的肠道微生物组、血浆细胞因子以及自我报告的睡眠质量和精神病理症状。
与健康对照者相比，失眠患者的肠道微生物群具有微生物丰富度和多样性较低、厌氧菌减少、产生短链脂肪酸（SCFA）的细菌减少以及潜在致病共生菌扩张的特征。 和 是区分急性失眠患者与健康对照者的标志性细菌，而 和 是区分慢性失眠患者与健康对照者的标志性细菌。急性/慢性失眠相关的标志性细菌也与这些患者自我报告的睡眠质量和血浆IL - 1β相关。
这些发现表明失眠症状、肠道微生物群和炎症可能以复杂的方式相互关联。肠道微生物群可能作为失眠辅助诊断的重要指标，并为睡眠障碍领域提供可能的新治疗靶点。
