Metabolic activation of the carcinogen 7,12-dimethylbenz[a]anthracene for DNA binding.

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作者信息

Moschel R C, Baird W M, Dipple A

出版信息

Biochem Biophys Res Commun. 1977 Jun 20;76(4):1092-8. doi: 10.1016/0006-291x(77)90968-8.

DOI:10.1016/0006-291x(77)90968-8

PMID:409395

Abstract

摘要

相似文献

Metabolic activation of the carcinogen 7,12-dimethylbenz[a]anthracene for DNA binding.

Biochem Biophys Res Commun. 1977 Jun 20;76(4):1092-8. doi: 10.1016/0006-291x(77)90968-8.

Cell and microsome mediated binding of 7,12-dimethylbenz(a)anthracene to DNA studied by fluorescence spectroscopy.通过荧光光谱法研究细胞和微粒体介导的7,12-二甲基苯并(a)蒽与DNA的结合。

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Photosensitivity of DNA-bound 7,12-dimethylbenz(alpha)anthracene.与DNA结合的7,12-二甲基苯并（α）蒽的光敏性。

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Differences between products of binding of 7,12-dimethylbenz[a]anthracene to DNA in mouse skin and in a rat liver microsomal system.

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[The effect of hydroxymethyl derivatives of 7,12-dimethylbenz(a)anthracene on its metabolism and toxic action in tissue culture].

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Additional evidence for the involvement of the 3,4-diol 1,2-oxides in the metabolic activation of 7,12-dimethylbenz[a]anthracene in mouse skin.关于3,4 - 二醇 - 1,2 - 环氧化物参与7,12 - 二甲基苯并[a]蒽在小鼠皮肤中代谢活化的更多证据。

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引用本文的文献

Formation of stable adducts and absence of depurinating DNA adducts in cells and DNA treated with the potent carcinogen dibenzo[a,l]pyrene or its diol epoxides.在用强效致癌物二苯并[a,l]芘或其二醇环氧化物处理的细胞和DNA中，稳定加合物的形成以及去嘌呤DNA加合物的缺失。

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Metabolism of 7,12-dimethylbenz[a]anthracene by Cunninghamella elegans.秀丽隐杆线虫对7,12-二甲基苯并[a]蒽的代谢

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Photoelectric properties and detection of the aromatic carcinogens benza[a]pyrene and dimethylbenzanthracene.

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Comparison of mutagenesis and malignant transformation by dihydrodiols from benz[a]anthracene and 7,12-dimethylbenz[a]anthracene.苯并[a]蒽和7,12-二甲基苯并[a]蒽的二氢二醇的诱变作用与恶性转化的比较。

Br J Cancer. 1979 May;39(5):540-7. doi: 10.1038/bjc.1979.99.

Identification of 7,12-dimethylbenz[a]anthracene metabolites that lead to mutagenesis in mammalian cells.鉴定导致哺乳动物细胞发生诱变的7,12-二甲基苯并[a]蒽代谢物。

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Identification of four trans-3,4-dihydrodiol metabolites of 7,12-dimethylbenz[a]anthracene and their in vitro DNA-binding activities upon further metabolism.7,12-二甲基苯并[a]蒽的四种反式-3,4-二氢二醇代谢物的鉴定及其进一步代谢后的体外DNA结合活性。

Proc Natl Acad Sci U S A. 1978 Nov;75(11):5466-70. doi: 10.1073/pnas.75.11.5466.

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