Grudzińska Ewa, Gajda Magdalena
Department of Gastrointestinal Surgery, Medical University of Silesia, 40-752 Katowice, Poland.
Cancers (Basel). 2025 Aug 26;17(17):2773. doi: 10.3390/cancers17172773.
Pancreatic cancer is one of the deadliest tumors, and surgery is, for now, the only potentially curative treatment. However, pancreatic surgery is burdened with severe complications, of which postoperative pancreatic fistula (POPF) is one of the most dangerous. Recent publications show that there is a strong connection between POPF and postoperative acute pancreatitis (POAP). In this review, we present the available literature on PPAP, summarizing the available diagnostic, prophylactic, and treatment tools. We identify POAP as a specific postoperative complication where a lack of unified definitions and treatment guidelines makes both research and clinical decisions more difficult. Based on the available studies, we also propose an algorithm for early POAP detection.
胰腺癌是最致命的肿瘤之一,目前手术是唯一可能治愈的治疗方法。然而,胰腺手术伴有严重并发症,其中术后胰瘘(POPF)是最危险的并发症之一。最近的出版物表明,POPF与术后急性胰腺炎(POAP)之间存在密切联系。在本综述中,我们展示了关于PPAP的现有文献,总结了可用的诊断、预防和治疗工具。我们将POAP确定为一种特定的术后并发症,由于缺乏统一的定义和治疗指南,使得研究和临床决策都更加困难。基于现有研究,我们还提出了一种早期POAP检测算法。