Ciapă Manuela Andreea, Donica Vlad Constantin, Costea Claudia Florida, Alexa Anisia Iuliana, Donica Alexandra Lori, Bogdănici Camelia Margareta
Doctoral School, Faculty of Medicine, University of Medicine and Pharmacy "Grigore T. Popa", University Street, No. 16, 700115 Iasi, Romania.
Department of Ophthalmology, Faculty of Medicine, University of Medicine and Pharmacy "Grigore T. Popa", University Street, No. 16, 700115 Iasi, Romania.
Diagnostics (Basel). 2025 Aug 28;15(17):2181. doi: 10.3390/diagnostics15172181.
Optic neuritis (ON) is a common manifestation of multiple sclerosis (MS), serving as a clinical window into central nervous system demyelination. Optical coherence tomography (OCT) and visual evoked potentials (VEPs) are complementary non-invasive tools for assessing structural and functional damage to the visual pathway. The objective of this paper is to evaluate correlations between OCT and VEP parameters in MS patients with and without a history of ON and assess their relationship with disease duration and disability (EDSS). This cross-sectional study included 54 eyes from 27 relapsing-remitting MS patients. OCT was used to measure circumpapillary and the temporal peripapillary retinal nerve fiber layer (pRNFL) and the foveal/parafoveal ganglion cell-inner plexiform layer (GCIPL) thickness. VEPs assessed P100 latency and amplitude. Patients were grouped by ON history. Eyes without ON showed a significantly greater circumpapillary pRNFL thickness (mean difference: 18.27 ± 5.33 µm, = 0.001), temporal pRNFL thickness (15.71 ± 5.49 µm, = 0.006), and parafoveal GCIPL thickness (12.85 ± 5.3 µm, = 0.019) compared to ON eyes. p100 latency was shorter and the amplitude was higher in NON eyes, but without statistical significance. Strong negative correlations were found between OCT thickness and EDSS and disease duration. p100 latency correlated negatively with OCT parameters, while amplitude showed a positive correlation with pRNFL thickness in ON eyes. OCT parameters, particularly pRNFL and GCIPL thickness, correlate with functional and clinical markers of MS. Combined OCT-VEP evaluation enhances the assessment of neurodegeneration and disease progression.
视神经炎（ON）是多发性硬化症（MS）的常见表现，是了解中枢神经系统脱髓鞘的临床窗口。光学相干断层扫描（OCT）和视觉诱发电位（VEP）是用于评估视觉通路结构和功能损伤的互补性非侵入性工具。本文的目的是评估有和没有ON病史的MS患者中OCT和VEP参数之间的相关性，并评估它们与疾病持续时间和残疾（扩展残疾状态量表[EDSS]）的关系。这项横断面研究纳入了27例复发缓解型MS患者的54只眼睛。使用OCT测量视乳头周围和颞侧视乳头周围视网膜神经纤维层（pRNFL）以及黄斑/旁黄斑神经节细胞-内丛状层（GCIPL）厚度。VEP评估P100潜伏期和波幅。患者按ON病史分组。与有ON的眼睛相比，没有ON的眼睛视乳头周围pRNFL厚度显著更大（平均差异：18.27±5.33µm，P = 0.001），颞侧pRNFL厚度（15.71±5.49µm，P = 0.006），以及旁黄斑GCIPL厚度（12.85±5.3µm，P = 0.019）。无ON眼睛的P100潜伏期更短且波幅更高，但无统计学意义。发现OCT厚度与EDSS和疾病持续时间之间存在强负相关。在有ON的眼睛中，P100潜伏期与OCT参数呈负相关，而波幅与pRNFL厚度呈正相关。OCT参数，特别是pRNFL和GCIPL厚度，与MS的功能和临床指标相关。联合OCT-VEP评估可增强对神经退行性变和疾病进展的评估。
