[化学诱导脂质过氧化后心脏收缩功能障碍的预防]
[Prevention of disorders of the contractile function of the heart after chemical induction of lipid peroxides].
作者信息
Nurmukhambetov A N, Meerson F Z, Riabtseva T A, Kashcheeva E P
出版信息
Kardiologiia. 1985 Dec;25(12):88-91.
PMID:4094316
Abstract
Adriblastin was shown to activate considerably lipid peroxidation processes in the heart muscle, mostly through the suppression of antioxidant enzyme (superoxidedysmutase and catalase) activity, with myocardial contractility declining essentially as a result. Pretreatment with the synthetic antioxidant ionol prevented the adriblastin-induced depression of myocardial contractility.
摘要
阿霉素被证明能显著激活心肌中的脂质过氧化过程，主要是通过抑制抗氧化酶（超氧化物歧化酶和过氧化氢酶）的活性，结果心肌收缩力基本下降。用合成抗氧化剂离子醇预处理可防止阿霉素引起的心肌收缩力抑制。
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