Brueggemann Petra, Grando Sória Marília, Schlaefke Sandra, Funk Petra, Mazurek Birgit
Tinnitus Center, Charité-Universitätsmedizin Berlin, 10117 Berlin, Germany.
Research & Development, Dr. Willmar Schwabe GmbH & Co. KG, 76227 Karlsruhe, Germany.
J Clin Med. 2025 Sep 6;14(17):6313. doi: 10.3390/jcm14176313.
: Tinnitus often occurs alongside the emotional symptoms of anxiety and depression. The extract EGb 761 was shown to be effective in reducing neuropsychiatric symptoms in elderly patients with both dementia and tinnitus, exerting direct effects on tinnitus severity and indirect effects mediated by improvement of anxiety, depression, and cognition. Whether the extent of the effects is influenced by the patient's sex has not yet been investigated. We performed a conditional process analysis to evaluate this question. : We analyzed the moderating role of sex on the direct and indirect effects of EGb 761 on tinnitus severity using a first- and second-stage conditional process model. : Indirect effects of EGb 761 on tinnitus severity mediated by improved cognition, anxiety, and depression did not differ between women and men ( > 0.05; all 95% bootstrap confidence intervals overlapped with zero). Moreover, direct treatment effects of EGb 761 on tinnitus severity were statistically significant for both sexes (women, < 0.0001; men, = 0.0279). : Beneficial effects of extract EGb 761 in dementia patients with tinnitus are likely to be unaffected by the patient's sex. Further research into the influence of patient characteristics on the outcome of tinnitus drug treatment is encouraged.
耳鸣常与焦虑和抑郁等情绪症状同时出现。银杏叶提取物EGb 761已被证明对患有痴呆和耳鸣的老年患者减轻神经精神症状有效，对耳鸣严重程度有直接影响，对焦虑、抑郁和认知改善介导的间接影响也有作用。这些影响的程度是否受患者性别影响尚未得到研究。我们进行了条件过程分析来评估这个问题。我们使用一阶和二阶条件过程模型分析了性别对EGb 761对耳鸣严重程度的直接和间接影响的调节作用。EGb 761通过改善认知、焦虑和抑郁对耳鸣严重程度的间接影响在女性和男性之间没有差异（>0.05；所有95%的自助置信区间与零重叠）。此外，EGb 761对耳鸣严重程度的直接治疗效果在两性中均具有统计学意义（女性，<0.0001；男性，=0.0279）。银杏叶提取物EGb 761对患有耳鸣的痴呆患者的有益作用可能不受患者性别的影响。鼓励进一步研究患者特征对耳鸣药物治疗结果的影响。
